{"id":"W2781438577","doi":"10.1074/jbc.m117.808675","title":"Countervailing, time-dependent effects on host autophagy promote intracellular survival of Leishmania","year":2017,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Autophagy; PI3K/AKT/mTOR pathway; Cell biology; ATG5; Leishmania; Biology; Protein kinase B; Intracellular parasite; Context (archaeology); Intracellular; Leishmania major; Signal transduction; Apoptosis; Biochemistry; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001673273,0.0002968546,0.0002009482,0.0001409829,0.0001164008,0.0004081365,0.0002052461,0.0002296917,0.001399928],"category_scores_gemma":[0.0001582638,0.0001129529,0.0002190856,0.0001220531,0.0002015232,0.0003430858,0.0002368759,0.000595002,0.0002365425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002593375,"about_ca_system_score_gemma":0.0002399606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002295667,"about_ca_topic_score_gemma":0.0009848389,"domain_scores_codex":[0.9998775,0.00002297322,0.00001406956,0.00002313945,0.00002818708,0.0000342313],"domain_scores_gemma":[0.9999149,0.0000159902,0.00002405822,0.00001356994,0.00001394667,0.00001750373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003836389,0.00005705197,0.00008655691,0.00004002433,0.000004880255,0.00002384175,0.00001272807,0.00004428844,0.9967641,0.0002817787,0.00009061524,0.002210518],"study_design_scores_gemma":[0.00004574981,0.0007490204,0.001527136,0.00000782678,0.00001945133,0.0001193859,0.00002021272,0.0005080979,0.9939854,0.00008816834,0.002923586,0.000006016656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939436,0.002016565,0.001524573,0.0002068626,0.000102164,0.0000204178,0.0002200005,0.00007609985,0.001889609],"genre_scores_gemma":[0.9959089,0.0007528853,0.001018233,0.00007093829,0.00002551488,0.00002218281,0.0001783957,0.00001716658,0.002005772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001399928,"threshold_uncertainty_score":0.004683256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01820080903345727,"score_gpt":0.281086203423373,"score_spread":0.2628853943899158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}