{"id":"W2781496272","doi":"10.1158/2326-6066.cir-17-0383","title":"Soluble SLAMF6 Receptor Induces Strong CD8+ T-cell Effector Function and Improves Anti-Melanoma Activity <i>In Vivo</i>","year":2018,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Rosetrees Trust","keywords":"Ectodomain; CD8; Cancer research; Cytotoxic T cell; Immunotherapy; Melanoma; T cell; Cytolysis; Biology; Immunology; Cancer immunotherapy; Immune system; Receptor; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001108825,0.0003827404,0.0003031011,0.0001769725,0.00007270893,0.0001768281,0.0001556583,0.0002552385,0.001356067],"category_scores_gemma":[0.00009002446,0.00008102325,0.000226565,0.0000839785,0.0001290656,0.0001487517,0.00009541345,0.0007407865,0.0005140513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001391036,"about_ca_system_score_gemma":0.00011599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002657287,"about_ca_topic_score_gemma":0.0003468881,"domain_scores_codex":[0.9998965,0.00001875305,0.000008847323,0.00001215689,0.00002093657,0.00004279459],"domain_scores_gemma":[0.9999386,0.000006660718,0.00001511117,0.000007279484,0.000007305725,0.00002500127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005187762,0.0003007264,0.0001230176,0.00003258837,0.000007680891,0.00004513381,0.000006572641,0.00008008719,0.9942787,0.00003780599,0.0002131701,0.00435569],"study_design_scores_gemma":[0.0002277308,0.007475944,0.004178165,0.000007288128,0.00003399953,0.0005113155,0.00001747538,0.0009019512,0.9837512,0.00004032819,0.002849584,0.00000489935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957114,0.001006751,0.00106959,0.000136672,0.00007177531,0.00004114181,0.0002362189,0.0001841302,0.001542228],"genre_scores_gemma":[0.9958761,0.000441323,0.0009575296,0.00006821076,0.00002446966,0.00002748363,0.0005620202,0.00001938584,0.002023401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001356067,"threshold_uncertainty_score":0.00453651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03098202432855256,"score_gpt":0.3138554816612241,"score_spread":0.2828734573326716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}