{"id":"W2781496272","doi":"10.1158/2326-6066.cir-17-0383","title":"Soluble SLAMF6 Receptor Induces Strong CD8+ T-cell Effector Function and Improves Anti-Melanoma Activity <i>In Vivo</i>","year":2018,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Rosetrees Trust","keywords":"Ectodomain; CD8; Cancer research; Cytotoxic T cell; Immunotherapy; Melanoma; T cell; Cytolysis; Biology; Immunology; Cancer immunotherapy; Immune system; Receptor; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0009607999,0.0002589016,0.000393873,0.0004951895,0.0006059805,0.00005796626,0.000278812,0.0006018281,0.003953374],"category_scores_gemma":[0.0001217286,0.0002428297,0.00007059256,0.000435746,0.001161375,0.0004283209,0.0002671113,0.001453663,0.001289963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002594469,"about_ca_system_score_gemma":0.0002043679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001720615,"about_ca_topic_score_gemma":0.0002407535,"domain_scores_codex":[0.9970539,0.0009651561,0.0003137797,0.0006721055,0.00008632253,0.0009087965],"domain_scores_gemma":[0.9987329,0.0003647664,0.0001297979,0.000427612,0.0003111491,0.00003379835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001949264,0.000198703,0.005366561,0.00003421698,0.0001515727,0.000001001317,0.0002375621,3.073981e-7,0.9636813,0.00008517138,0.01717647,0.01111787],"study_design_scores_gemma":[0.002790783,0.00166002,0.02728431,0.00005609036,0.00001697795,0.00001114387,0.0004797825,0.00001062675,0.8529748,0.00002638221,0.1144639,0.0002252204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791356,0.007651458,0.00002703274,0.000418956,0.008689118,0.0005272148,0.000008231481,0.00008000792,0.003462373],"genre_scores_gemma":[0.9763093,0.001247775,0.000006950945,0.00008105702,0.0001974622,0.0002146548,0.00002900355,0.0000342761,0.02187954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1107065,"threshold_uncertainty_score":0.9994876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03098202432855256,"score_gpt":0.3138554816612241,"score_spread":0.2828734573326716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}