{"id":"W2781534817","doi":"10.3389/fphys.2017.01108","title":"Deficiency of Carbonic Anhydrase II Results in a Urinary Concentrating Defect","year":2018,"lang":"en","type":"article","venue":"Frontiers in Physiology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Medical Research Council; Novo Nordisk Fonden; Aarhus Universitet; Kidney Foundation of Canada; H. Lundbeck A/S; Lundbeckfonden; Stollery Children’s Hospital Foundation; Children's Hospital Foundation; Canadian Institutes of Health Research; A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal; Women and Children's Health Research Institute; Sundhed og Sygdom, Det Frie Forskningsråd; Novo Nordisk","keywords":"Carbonic anhydrase; Urinary system; Carbonic anhydrase II; Medicine; Chemistry; Endocrinology; Biology; Internal medicine; Physiology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001683226,0.001442988,0.0006079392,0.0009586968,0.000370033,0.0003806347,0.0005668392,0.001019716,0.0039056],"category_scores_gemma":[0.000258871,0.0003471983,0.0005159422,0.0003839938,0.0007232791,0.0002762411,0.0005900926,0.0008060483,0.001128452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004225343,"about_ca_system_score_gemma":0.0003900001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001360441,"about_ca_topic_score_gemma":0.002005848,"domain_scores_codex":[0.999512,0.00003288485,0.00007316504,0.0001811168,0.0001299416,0.00007092393],"domain_scores_gemma":[0.9994662,0.00005897395,0.0001664326,0.00003679012,0.00003926227,0.0002321887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002745908,0.0001188754,0.001119316,0.0001132108,0.00002891156,0.002396609,0.00004519616,0.00006908023,0.9928647,0.0002701371,0.0002622446,0.0024371],"study_design_scores_gemma":[0.0001589128,0.001154002,0.04844518,0.00008653529,0.0001845352,0.02250329,0.0001431975,0.001182411,0.9036862,0.0003758098,0.02202039,0.00005951631],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768461,0.003067942,0.009113076,0.0004240107,0.0001708392,0.0001925103,0.004883131,0.0008251332,0.004477277],"genre_scores_gemma":[0.9738743,0.002485939,0.006629358,0.0002848944,0.00005704548,0.0001463847,0.003883904,0.0002534601,0.01238467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0039056,"threshold_uncertainty_score":0.01306552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006195341477104917,"score_gpt":0.2245511369129194,"score_spread":0.2183557954358145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}