{"id":"W2781534817","doi":"10.3389/fphys.2017.01108","title":"Deficiency of Carbonic Anhydrase II Results in a Urinary Concentrating Defect","year":2018,"lang":"en","type":"article","venue":"Frontiers in Physiology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Medical Research Council; Novo Nordisk Fonden; Aarhus Universitet; Kidney Foundation of Canada; H. Lundbeck A/S; Lundbeckfonden; Stollery Children’s Hospital Foundation; Children's Hospital Foundation; Canadian Institutes of Health Research; A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal; Women and Children's Health Research Institute; Sundhed og Sygdom, Det Frie Forskningsråd; Novo Nordisk","keywords":"Carbonic anhydrase; Urinary system; Carbonic anhydrase II; Medicine; Chemistry; Endocrinology; Biology; Internal medicine; Physiology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001244306,0.00008995448,0.0001604936,0.00006838801,0.00003278026,0.000001043234,0.0001045582,0.0001333936,0.000003098868],"category_scores_gemma":[0.00002983942,0.00008991879,0.00005442512,0.0001401684,0.0001899606,0.000003223783,0.00003307297,0.0000615079,5.58123e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001573158,"about_ca_system_score_gemma":0.00005273291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004068738,"about_ca_topic_score_gemma":0.00006315349,"domain_scores_codex":[0.9991652,0.00005506992,0.0002545371,0.000262417,0.00004676074,0.0002159581],"domain_scores_gemma":[0.9996806,0.000004312742,0.00008422665,0.0001759616,0.00003339731,0.00002145485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001028737,0.0002097637,0.02767656,0.0000309756,0.00001526528,0.000005324213,0.0006392822,0.0004466958,0.9679863,0.00008745088,0.0008262336,0.001047456],"study_design_scores_gemma":[0.005430622,0.004570161,0.4557039,0.0001116792,0.00002539128,0.00001154687,0.0007510675,0.004220524,0.5234177,0.002543496,0.002656563,0.0005574343],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977038,0.0007314026,0.000296024,0.00002323753,0.0003788673,0.000106239,0.000009405296,0.000004052756,0.0007470106],"genre_scores_gemma":[0.9990874,0.00006030804,0.0005185364,0.00003343938,0.0001241073,0.000007760257,0.0001144489,0.000007417889,0.00004657946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4445686,"threshold_uncertainty_score":0.3666782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006195341477104917,"score_gpt":0.2245511369129194,"score_spread":0.2183557954358145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}