{"id":"W2781602382","doi":"10.3389/fncir.2017.00107","title":"Opposing Cholinergic and Serotonergic Modulation of Layer 6 in Prefrontal Cortex","year":2018,"lang":"en","type":"article","venue":"Frontiers in Neural Circuits","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Alzheimer Society Research Program; Canada Foundation for Innovation; Canadian Institutes of Health Research; Alzheimer Society; Children’s Hospital of Wisconsin Research Institute; Seattle Children's Research Institute; University of Washington","keywords":"Neuroscience; Prefrontal cortex; Serotonergic; Optogenetics; Acetylcholine; Cholinergic; Pyramidal cell; Neuromodulation; Biology; Chemistry; Serotonin; Central nervous system; Endocrinology; Hippocampus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001284432,0.0002910541,0.0002569859,0.0001981738,0.0001461496,0.0003354494,0.0002567307,0.0002814863,0.0006412052],"category_scores_gemma":[0.0002116594,0.000224463,0.0003437334,0.00008286007,0.0002558288,0.00031715,0.0003307873,0.0005578921,0.0001173573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004163222,"about_ca_system_score_gemma":0.0003107521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002113786,"about_ca_topic_score_gemma":0.004490628,"domain_scores_codex":[0.9998584,0.000009818193,0.00001386044,0.00003452301,0.00004261153,0.00004076811],"domain_scores_gemma":[0.9998745,0.00001352434,0.00004627039,0.00001073996,0.00002038198,0.0000345782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005188098,0.000002819035,0.0002710393,0.00003327457,0.000008254734,0.00002567068,0.00001367503,0.00003095739,0.9990456,0.00003214681,0.000005682054,0.0004791144],"study_design_scores_gemma":[0.00003048482,0.0002862638,0.1171461,0.00004092599,0.00009110654,0.0005841012,0.0001637391,0.001510934,0.8789904,0.000210515,0.0009286826,0.00001678456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995752,0.001469004,0.001827698,0.00007669283,0.00001316536,0.000009185739,0.000164554,0.00002538599,0.0006622171],"genre_scores_gemma":[0.9963408,0.0009450204,0.001539051,0.00006146677,0.000005578354,0.00001312833,0.0001266975,0.00001036988,0.0009578137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002113786,"threshold_uncertainty_score":0.004202902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01351329302380806,"score_gpt":0.2448055373970452,"score_spread":0.2312922443732372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}