{"id":"W2781690103","doi":"10.3389/fcimb.2017.00528","title":"The Toolbox for Uncovering the Functions of Legionella Dot/Icm Type IVb Secretion System Effectors: Current State and Future Directions","year":2018,"lang":"en","type":"review","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Queen's University Belfast","keywords":"Effector; Legionella pneumophila; Secretion; Biology; Virulence; Legionella; Intracellular parasite; Intracellular; Cell biology; Mutant; Computational biology; Gene; Microbiology; Genetics; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005725503,0.0002625014,0.0004845111,0.0001316617,0.0004227732,0.00004490332,0.0001298376,0.0003130862,0.000001025675],"category_scores_gemma":[0.00004317889,0.0001588718,0.000202303,0.0002326336,0.0003683251,0.000006803305,0.0001008733,0.0002875405,0.000002509295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006802241,"about_ca_system_score_gemma":0.0001249075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000416072,"about_ca_topic_score_gemma":0.00005411338,"domain_scores_codex":[0.9984998,0.0003641452,0.0003956525,0.0004198091,0.00004142335,0.0002792418],"domain_scores_gemma":[0.999211,0.00008140512,0.0002351868,0.0002970893,0.0001313472,0.00004396561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002658991,0.00009780321,0.0010304,0.01015601,0.0007683547,0.000001195572,0.0001370525,0.000008821386,0.01389591,0.0000968883,0.03686869,0.936673],"study_design_scores_gemma":[0.0002670773,0.000304385,0.00001474631,0.0004210968,0.0001495411,0.00005275779,0.00004988378,0.00002568147,0.0004118369,0.00001561788,0.9981182,0.0001692413],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006019785,0.9837857,0.003705429,0.00002492312,0.00526493,0.001033561,0.00009876883,0.000009253861,0.00005766813],"genre_scores_gemma":[0.001722474,0.9962977,0.00003387863,0.000005396191,0.0009475431,0.0001370556,0.0004603184,0.00002829082,0.0003673896],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9612495,"threshold_uncertainty_score":0.6478604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01292811939425831,"score_gpt":0.2688602250314813,"score_spread":0.255932105637223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}