{"id":"W2781752934","doi":"10.1080/10428194.2017.1416364","title":"Improvement of fatigue, physical functioning, and well-being among patients with severe impairment at baseline receiving ibrutinib in combination with bendamustine and rituximab for relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma in the HELIOS study","year":2018,"lang":"en","type":"article","venue":"Leukemia & lymphoma/Leukemia and lymphoma","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"Johnson and Johnson; Astellas Pharma; Celgene; Gilead Sciences","keywords":"Bendamustine; Ibrutinib; Medicine; Chronic lymphocytic leukemia; Internal medicine; Placebo; Quality of life (healthcare); Rituximab; Clinical endpoint; Oncology; Clinical trial; Lymphoma; Leukemia; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.002096185,0.001370617,0.001979974,0.0009855222,0.000785641,0.0002363083,0.0005519969,0.0004948088,0.00002777718],"category_scores_gemma":[0.0003846869,0.001013931,0.0001907354,0.001710047,0.001508371,0.0006028214,0.0006112783,0.0002730178,0.000008725726],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.1652357,"about_ca_system_score_gemma":0.02465309,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01076908,"about_ca_topic_score_gemma":0.005020913,"domain_scores_codex":[0.9919239,0.0004710378,0.001765265,0.002234711,0.001744315,0.001860748],"domain_scores_gemma":[0.9949017,0.001583787,0.0008685233,0.001379018,0.0006762335,0.000590713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06491352,0.009052085,0.6217577,0.008832851,0.002244373,0.00146913,0.04692668,0.002815086,0.002502535,0.000650513,0.0007778836,0.2380576],"study_design_scores_gemma":[0.3549048,0.01638027,0.4169529,0.002367069,0.0007882678,0.0009302142,0.003644736,0.1997357,0.002700585,0.0001113257,0.000231827,0.001252244],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914584,0.0005379183,0.0001711876,0.00006202502,0.0001648994,0.006827876,0.00003811637,0.0001409856,0.0005985842],"genre_scores_gemma":[0.9965786,0.0002361419,0.0005061583,0.0003557901,0.0003363784,0.001065815,0.0002381199,0.0002359157,0.0004471044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2899913,"threshold_uncertainty_score":0.9999045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0091424588777352,"score_gpt":0.2451292454810516,"score_spread":0.2359867866033163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}