{"id":"W2781752934","doi":"10.1080/10428194.2017.1416364","title":"Improvement of fatigue, physical functioning, and well-being among patients with severe impairment at baseline receiving ibrutinib in combination with bendamustine and rituximab for relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma in the HELIOS study","year":2018,"lang":"en","type":"article","venue":"Leukemia & lymphoma/Leukemia and lymphoma","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"Johnson and Johnson; Astellas Pharma; Celgene; Gilead Sciences","keywords":"Bendamustine; Ibrutinib; Medicine; Chronic lymphocytic leukemia; Internal medicine; Placebo; Quality of life (healthcare); Rituximab; Clinical endpoint; Oncology; Clinical trial; Lymphoma; Leukemia; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00226594,0.0006939638,0.001388303,0.0002665015,0.0002191543,0.0005320581,0.0003332311,0.0005679246,0.001383117],"category_scores_gemma":[0.001287767,0.0003455773,0.001148874,0.0002664428,0.0003823495,0.0004917085,0.000401795,0.0009697155,0.0002334697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003426343,"about_ca_system_score_gemma":0.0004197417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005880292,"about_ca_topic_score_gemma":0.001184912,"domain_scores_codex":[0.9992917,0.0004191555,0.00005348542,0.0000778491,0.0000796217,0.00007820904],"domain_scores_gemma":[0.9994184,0.0001383433,0.0001676314,0.00004784891,0.00003560155,0.0001921563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7622584,0.02138928,0.1437766,0.0006637002,0.006005866,0.0001468512,0.0004248619,0.001033594,0.01382418,0.00007323892,0.00153816,0.04886531],"study_design_scores_gemma":[0.246922,0.3070792,0.4365175,0.00007999551,0.003348205,0.000194616,0.0002172194,0.001300353,0.002133565,0.0000895773,0.00207206,0.00004565685],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984788,0.0008418412,0.00004746377,0.00004620841,0.0000161171,0.0001053281,0.0001937356,0.000005342618,0.0002652047],"genre_scores_gemma":[0.9984574,0.0003104592,0.00008829734,0.0001014524,0.00005549313,0.0002079507,0.0004995406,0.000001909842,0.0002774339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00226594,"threshold_uncertainty_score":0.01198363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0091424588777352,"score_gpt":0.2451292454810516,"score_spread":0.2359867866033163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}