{"id":"W2781762092","doi":"10.1016/j.jconrel.2018.01.001","title":"Mechanistic understanding the bioeffects of ultrasound-driven microbubbles to enhance macromolecule delivery","year":2018,"lang":"en","type":"review","venue":"Journal of Controlled Release","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":170,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"Shanghai Jiao Tong University; National Natural Science Foundation of China","keywords":"Microbubbles; Sonoporation; Cavitation; Endocytosis; Supercavitation; Nanotechnology; Ultrasound; Chemistry; Biophysics; Materials science; Biology; Medicine; Cell; Mechanics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004239774,0.0003671399,0.001845444,0.0002760525,0.0001189436,0.00006862538,0.0005828053,0.0001916792,0.00004930583],"category_scores_gemma":[0.0002897056,0.0002238466,0.0009018349,0.0003568317,0.00007841227,0.00005489932,0.00002464681,0.0004436683,0.00004950525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002539766,"about_ca_system_score_gemma":0.0002097172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002662225,"about_ca_topic_score_gemma":0.000005993032,"domain_scores_codex":[0.9980609,0.0001696653,0.001060072,0.0001597916,0.000275273,0.0002743391],"domain_scores_gemma":[0.9969871,0.001632271,0.0006710295,0.0003546315,0.0001851295,0.0001698533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002107147,0.001341428,0.000002851783,0.06046978,0.03006314,0.0005256705,0.0026664,0.0115508,0.2258732,0.0119136,0.06297351,0.5905125],"study_design_scores_gemma":[0.003621936,0.0006738859,4.804514e-7,0.02267821,0.008452841,0.001164626,0.0002344549,0.0006911533,0.001627868,0.001257618,0.9585329,0.001064009],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002970043,0.9356713,0.06213681,0.0000305907,0.0004004045,0.0009801213,0.00005473294,0.00002922106,0.0003998257],"genre_scores_gemma":[0.03321407,0.9654341,0.0006842805,0.0000422961,0.0004049586,0.00005242639,0.000005556323,0.00008046551,0.00008187226],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8955594,"threshold_uncertainty_score":0.9128199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01856449137970124,"score_gpt":0.2758432594031314,"score_spread":0.2572787680234302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}