{"id":"W2781765654","doi":"10.1074/jbc.ra117.000698","title":"Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Versus Arthritis; Canadian Institutes of Health Research; Rosetrees Trust; Cancer Research UK; Wellcome Trust","keywords":"Biology; Demethylase; Cytokine; Cell biology; Immune system; Innate immune system; Epigenetics; Cancer research; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000124449,0.0002618002,0.0002535414,0.0001482529,0.00008773687,0.0001551682,0.0001810509,0.0001200038,0.001221751],"category_scores_gemma":[0.0001049967,0.00009170389,0.0002487022,0.0001117199,0.0001719564,0.0001047845,0.0001491215,0.0004078131,0.0002037628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001600465,"about_ca_system_score_gemma":0.0001953453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004925292,"about_ca_topic_score_gemma":0.0009696481,"domain_scores_codex":[0.999903,0.00001209939,0.00001024615,0.00002060541,0.00001857098,0.00003552691],"domain_scores_gemma":[0.9999481,0.00001163971,0.00001304394,0.000007182459,0.000005674434,0.00001434201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004005504,0.00004923352,0.000158657,0.00006054897,0.00001431855,0.000022931,0.000008768537,0.0001028786,0.9971421,0.00003819081,0.00006347039,0.001938325],"study_design_scores_gemma":[0.00005243089,0.000602567,0.002559962,0.000003520502,0.00002869594,0.00005932259,0.00001618314,0.0005102289,0.9943272,0.00002936961,0.001806952,0.000003520297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993083,0.002769973,0.001608955,0.00008540473,0.00005704971,0.00003886202,0.000320194,0.0001076172,0.0019289],"genre_scores_gemma":[0.9958763,0.001423934,0.0006359108,0.00005355498,0.00001093507,0.00003481229,0.0003397081,0.00001535731,0.001609429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001221751,"threshold_uncertainty_score":0.00408715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01120839473974047,"score_gpt":0.2462925963909997,"score_spread":0.2350842016512593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}