{"id":"W2781797914","doi":"10.3389/fimmu.2017.01885","title":"Efficacy of a Virus-Like Nanoparticle As Treatment for a Chronic Viral Infection Is Hindered by IRAK1 Regulation and Antibody Interference","year":2018,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Fondation Jean-Louis Lévesque; Institut national de la recherche scientifique","keywords":"Antibody; Virus; Virology; Medicine; Immunology; RNA interference; Viral infection; Interference (communication); Biology; Computer science; Genetics; Telecommunications; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001972166,0.0002459958,0.0003170242,0.00009327677,0.00009408568,0.000242816,0.0001556351,0.0003261462,0.0006503831],"category_scores_gemma":[0.0001119343,0.0000895275,0.0002446857,0.0000571351,0.0001775012,0.0001667734,0.000152363,0.0004352802,0.0001962874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001480539,"about_ca_system_score_gemma":0.0001639917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001383158,"about_ca_topic_score_gemma":0.0001920608,"domain_scores_codex":[0.9998753,0.00001954868,0.000009947595,0.00003198116,0.00002920545,0.00003406202],"domain_scores_gemma":[0.9999373,0.00001843267,0.00001622732,0.000007307548,0.00001100919,0.000009805623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006348883,0.00002797957,0.00005611511,0.00005094401,0.000003701779,0.00001579768,0.000008046466,0.0000463855,0.9979894,0.00005667795,0.00002049203,0.001660911],"study_design_scores_gemma":[0.00001965212,0.0007891156,0.0007064752,0.000007585887,0.00001924413,0.0001235306,0.00000990605,0.0008015588,0.9952646,0.00004748501,0.002207914,0.000002933539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811555,0.004946986,0.01138566,0.0001735662,0.00008941823,0.00008908899,0.00009431127,0.00009458905,0.001970689],"genre_scores_gemma":[0.9915329,0.001474109,0.004994241,0.00007859648,0.00001675635,0.00008248121,0.0001169702,0.00001423921,0.001689616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006503831,"threshold_uncertainty_score":0.002175748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03102077433442861,"score_gpt":0.3583073237722855,"score_spread":0.3272865494378569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}