{"id":"W2781799235","doi":"10.1111/vco.12380","title":"In vitro efficacy of a first‐generation valosin‐containing protein inhibitor (CB‐5083) against canine lymphoma","year":2018,"lang":"en","type":"article","venue":"Veterinary and Comparative Oncology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Canine Lymphoma; Unfolded protein response; Cytotoxicity; Apoptosis; Biology; Cancer research; ATF4; Molecular biology; Lymphoma; Chemistry; In vitro; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001761309,0.0002904891,0.0003188006,0.0002373977,0.0001075761,0.000228216,0.0002140338,0.0002273701,0.001152153],"category_scores_gemma":[0.0001162671,0.0001071798,0.0001988429,0.0001798052,0.0001184548,0.0001414826,0.0001057429,0.0004613281,0.0003353787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002380948,"about_ca_system_score_gemma":0.0002348468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001274131,"about_ca_topic_score_gemma":0.001534188,"domain_scores_codex":[0.9998915,0.00002677102,0.00001255077,0.00001898598,0.00002608661,0.00002405302],"domain_scores_gemma":[0.9999173,0.00002236952,0.00001634262,0.000009689251,0.00001448549,0.00001980732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008476336,0.0003706589,0.0002079653,0.0001067933,0.00001717309,0.00005478407,0.00002179943,0.0004130155,0.9940884,0.00005683791,0.000218549,0.003596334],"study_design_scores_gemma":[0.00009335133,0.004318305,0.002911026,0.000009639617,0.00006033311,0.000177651,0.00001620913,0.00131799,0.9887137,0.0000240226,0.002351541,0.000006260332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917889,0.004345285,0.0009137575,0.00008035795,0.0000548597,0.00005630653,0.0006229148,0.00006773249,0.002070026],"genre_scores_gemma":[0.9943628,0.001750136,0.0008293875,0.00003868448,0.00001536416,0.00005169974,0.001129231,0.00001209762,0.001810554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001274131,"threshold_uncertainty_score":0.003854334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04475597655718774,"score_gpt":0.3181428842690704,"score_spread":0.2733869077118827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}