{"id":"W2781829400","doi":"10.1523/jneurosci.2793-17.2017","title":"The Stress-Induced Transcription Factor NR4A1 Adjusts Mitochondrial Function and Synapse Number in Prefrontal Cortex","year":2018,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université Laval","funders":"National Institute on Aging; Pfizer; Institut National de la Santé et de la Recherche Médicale; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Chronic stress; Prefrontal cortex; Neuroscience; Synapse; Synaptic plasticity; Dendritic spine; Gene knockdown; Biology; Transcription factor; Social defeat; Mitochondrion; Cell biology; Gene; Cognition; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001063486,0.0001857282,0.0002315067,0.0001915825,0.0002361074,0.0002277528,0.0002836045,0.0002057314,0.001135371],"category_scores_gemma":[0.0001965847,0.0002010766,0.0002542337,0.0001141929,0.0002729776,0.0002169218,0.0002636784,0.0004269996,0.000282942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006948145,"about_ca_system_score_gemma":0.0003498162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003923677,"about_ca_topic_score_gemma":0.004722828,"domain_scores_codex":[0.9998701,0.000008324945,0.000007982867,0.00005747807,0.00002402788,0.00003209777],"domain_scores_gemma":[0.999878,0.000006285589,0.00004563181,0.00001317757,0.00002627852,0.0000306222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001798051,0.00001559389,0.00156545,0.00002920363,0.000009855995,0.00002930122,0.00002915505,0.00006288541,0.9958383,0.00004820521,0.00007411614,0.002118113],"study_design_scores_gemma":[0.0001127215,0.0006922768,0.3004998,0.00003774723,0.0001148292,0.0008206359,0.0004377361,0.005185463,0.6863779,0.0007544552,0.004925614,0.00004075816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953793,0.001181462,0.002281763,0.000133202,0.0000297837,0.000008304105,0.0003173491,0.00007282884,0.0005960181],"genre_scores_gemma":[0.9960909,0.0005952782,0.001155101,0.00006728193,0.000007435865,0.00002197666,0.0003028713,0.00002421274,0.001734786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003923677,"threshold_uncertainty_score":0.007801712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03485265443098289,"score_gpt":0.2741190290677134,"score_spread":0.2392663746367305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}