{"id":"W2781853768","doi":"10.1038/s41598-017-18719-7","title":"Acetaldehyde inhibits retinoic acid biosynthesis to mediate alcohol teratogenicity","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Prenatal Substance Exposure Effects","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Acetaldehyde; Retinoic acid; Alcohol dehydrogenase; Ethanol; Aldehyde dehydrogenase; Biochemistry; Chemistry; Alcohol; Enzyme; Pharmacology; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002371701,0.000288267,0.0004470492,0.0003658124,0.0003460083,0.0001837101,0.000195887,0.000152733,0.0005135051],"category_scores_gemma":[0.002096221,0.0002412453,0.0001786195,0.001351076,0.0005215721,0.0002371735,0.0002164704,0.0001949226,0.001126821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001477373,"about_ca_system_score_gemma":0.0002369525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001369784,"about_ca_topic_score_gemma":0.00008248561,"domain_scores_codex":[0.99611,0.0000871891,0.000671706,0.001341603,0.001090984,0.0006985579],"domain_scores_gemma":[0.9968484,0.00005421627,0.0002674337,0.001744458,0.0004315594,0.0006539301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007761775,0.00008631167,0.009877631,0.00004115967,0.00004147187,0.001001366,0.0006053018,4.318654e-7,0.9481475,0.000007632307,0.03576206,0.004351516],"study_design_scores_gemma":[0.0002677633,0.0001844466,0.007228651,0.0002250414,0.00006092629,0.0008118282,0.00002078572,0.00001915211,0.9592063,0.0002920089,0.03142805,0.000255009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854859,0.0002635091,0.0001209726,0.000766297,0.007963452,0.0009752272,0.000006334221,0.0002846241,0.004133685],"genre_scores_gemma":[0.9943314,0.000002081363,0.001843976,0.000454986,0.0005969269,0.0000544168,0.0000388552,0.00004313482,0.002634263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01105884,"threshold_uncertainty_score":0.9996509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01707109761310133,"score_gpt":0.2725928300914374,"score_spread":0.2555217324783361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}