{"id":"W2781864143","doi":"10.1101/229195","title":"TIMELINE OF BRAIN ALTERATIONS IN ALZHEIMER’S DISEASE ACROSS THE ENTIRE LIFESPAN","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Drug Abuse; National Institute of Mental Health; Medical Research Council; University of California, San Diego; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, Los Angeles; Genentech; U.S. Food and Drug Administration; National Institutes of Health; Leon Levy Foundation; Centre National de la Recherche Scientifique; Cincinnati Children's Hospital Medical Center; Eisai; Northern California Institute for Research and Education; Alzheimer's Disease Neuroimaging Initiative; Medpace; Agence Nationale de la Recherche; F. Hoffmann-La Roche; GlaxoSmithKline; Bristol-Myers Squibb; Eli Lilly and Company; National Health and Medical Research Council; AstraZeneca; Pfizer; National Institute on Aging; Commonwealth Scientific and Industrial Research Organisation; Foundation for the National Institutes of Health; Elan; Novartis; National Institute of Child Health and Human Development; Synarc; Engineering and Physical Sciences Research Council; Dana Foundation; Alzheimer's Association","keywords":"Neuroscience; Hippocampus; Atrophy; Temporal lobe; Amygdala; Abnormality; Disease; Biomarker; Psychology; Medicine; Pathology; Biology; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003642694,0.0001482781,0.0001855186,0.0006214962,0.0001530014,0.0001887956,0.0001053694,0.0001883752,0.0007677671],"category_scores_gemma":[0.000887958,0.00007921725,0.0001701212,0.0003548228,0.0001253266,0.0002028043,0.0002945878,0.0002180798,0.0001573275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000143376,"about_ca_system_score_gemma":0.0001259565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002607435,"about_ca_topic_score_gemma":0.003511976,"domain_scores_codex":[0.9999323,0.00001395965,0.000005203095,0.00002779557,0.00001028982,0.00001043598],"domain_scores_gemma":[0.9996654,0.00004959899,0.0001257596,0.00004834867,0.00006206535,0.00004890282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000736348,0.00007503777,0.9203251,0.00008252847,0.0002896421,0.00040742,0.0005190752,0.003028526,0.03627811,0.0006960548,0.001335445,0.03622671],"study_design_scores_gemma":[0.0000023252,0.00008540491,0.9953815,0.00001147323,0.00003504426,0.0002799844,0.00008741864,0.001609345,0.001432996,0.000500278,0.0005684215,0.000005789527],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962684,0.0004790851,0.001180954,0.00004926009,0.000003598977,0.000005029299,0.001564683,0.00002601532,0.0004230168],"genre_scores_gemma":[0.9974834,0.000192074,0.0008345344,0.00001065616,0.000003404354,0.000009149629,0.001250422,0.000004993555,0.0002113328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002607435,"threshold_uncertainty_score":0.005184591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03759454663497673,"score_gpt":0.3255446168046413,"score_spread":0.2879500701696646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}