{"id":"W2781906226","doi":"10.1016/j.exger.2018.01.005","title":"Signal transduction changes in CD4 + and CD8 + T cell subpopulations with aging","year":2018,"lang":"en","type":"article","venue":"Experimental Gerontology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Ministerstwo Edukacji i Nauki; Agency for Science, Technology and Research; Université de Sherbrooke","keywords":"Immunosenescence; Cytotoxic T cell; CD28; Biology; T cell; CD8; Cell biology; Memory T cell; Immunology; Acquired immune system; Population; Signal transduction; PI3K/AKT/mTOR pathway; Effector; Immune system; Genetics; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0000791998,0.0001961461,0.0002701834,0.0001494018,0.000205539,0.000009058372,0.0001089897,0.0002400716,0.001882996],"category_scores_gemma":[0.000001863997,0.0001729177,0.00002484521,0.00009671021,0.000725501,0.00009029967,0.00004466333,0.000204887,0.0001373948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005090538,"about_ca_system_score_gemma":0.00002024647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005693629,"about_ca_topic_score_gemma":0.002597825,"domain_scores_codex":[0.9988174,0.0001617201,0.000191155,0.000386196,0.00002275344,0.000420774],"domain_scores_gemma":[0.9996889,0.00003685858,0.00007035567,0.0001593027,0.00002288387,0.00002169996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002470661,0.0002178888,0.005691945,0.000005139957,0.00003200839,0.000009878725,0.003615887,6.843882e-7,0.9886617,0.0002969058,0.0001610025,0.001059884],"study_design_scores_gemma":[0.002149669,0.001211211,0.002379964,0.00001155113,0.00001538848,0.0002934462,0.002756763,0.000005660008,0.9847937,0.00003418102,0.00613721,0.0002112897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900752,0.006407739,0.0001323247,0.0004291418,0.0005336074,0.0002031658,0.000004280737,0.00006234561,0.002152249],"genre_scores_gemma":[0.9979503,0.00003505435,0.0002127892,0.0001462475,0.00006879248,0.00004981017,0.00004998389,0.00001747379,0.001469528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007875174,"threshold_uncertainty_score":0.9990294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02172557175363577,"score_gpt":0.2599826110409166,"score_spread":0.2382570392872809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}