{"id":"W2781906226","doi":"10.1016/j.exger.2018.01.005","title":"Signal transduction changes in CD4 + and CD8 + T cell subpopulations with aging","year":2018,"lang":"en","type":"article","venue":"Experimental Gerontology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Ministerstwo Edukacji i Nauki; Agency for Science, Technology and Research; Université de Sherbrooke","keywords":"Immunosenescence; Cytotoxic T cell; CD28; Biology; T cell; CD8; Cell biology; Memory T cell; Immunology; Acquired immune system; Population; Signal transduction; PI3K/AKT/mTOR pathway; Effector; Immune system; Genetics; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001660811,0.0002621591,0.0002829393,0.0003440847,0.0001440755,0.0002325593,0.0001160593,0.0002613766,0.001763558],"category_scores_gemma":[0.0002362944,0.0001303367,0.0001945828,0.0001910151,0.000230197,0.0003235287,0.0001504258,0.0003247385,0.0002380761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001263713,"about_ca_system_score_gemma":0.00009165642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000378921,"about_ca_topic_score_gemma":0.0002326414,"domain_scores_codex":[0.9999121,0.00001245423,0.000007238891,0.00002803749,0.00001058906,0.00002941977],"domain_scores_gemma":[0.9999009,0.0000150047,0.00002468846,0.000009945138,0.00002113106,0.00002831323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006234063,0.0001347516,0.0140816,0.00005768508,0.00001926335,0.0002170399,0.0003652861,0.00004632599,0.9688428,0.0001309811,0.00008570725,0.009784404],"study_design_scores_gemma":[0.00008708746,0.003005506,0.6219518,0.00001774483,0.0001888839,0.001138533,0.001292362,0.0006974835,0.3690833,0.0006372715,0.001872748,0.00002732917],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990434,0.0004033092,0.000180867,0.0000146373,0.00001055262,0.000002882208,0.00007709729,0.000009078101,0.0002581184],"genre_scores_gemma":[0.9981363,0.0002659187,0.0001792433,0.00002447596,0.00001460165,0.0000193131,0.0001141628,0.000004666929,0.0012413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001763558,"threshold_uncertainty_score":0.005899668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02172557175363577,"score_gpt":0.2599826110409166,"score_spread":0.2382570392872809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}