{"id":"W2781926451","doi":"10.1016/j.jsbmb.2018.01.004","title":"Bisphenol A stimulates adrenal cortical cell proliferation via ERβ-mediated activation of the sonic hedgehog signalling pathway","year":2018,"lang":"en","type":"article","venue":"The Journal of Steroid Biochemistry and Molecular Biology","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"Cyclopamine; Sonic hedgehog; Endocrinology; Internal medicine; Cell growth; Biology; Hedgehog signaling pathway; Signal transduction; Estrogen receptor; Estrogen receptor alpha; Cell biology; Chemistry; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008435734,0.0004177894,0.0001520822,0.0004050777,0.0001931723,0.0002356242,0.0001867482,0.0001957187,0.002340231],"category_scores_gemma":[0.0001449087,0.0001884153,0.0003601326,0.0001972762,0.0002264402,0.0002126889,0.000366261,0.0004527013,0.0003850119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003098604,"about_ca_system_score_gemma":0.0003528698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003372655,"about_ca_topic_score_gemma":0.003704978,"domain_scores_codex":[0.9999,0.00001732793,0.000006778781,0.00001451987,0.00002671965,0.00003469384],"domain_scores_gemma":[0.9999084,0.00001825172,0.00001737065,0.00001185424,0.00001607174,0.0000279035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00072303,0.00008129968,0.0005639292,0.0000737971,0.00002236234,0.00009461937,0.00003559818,0.00008650395,0.9938938,0.0001375229,0.0001209331,0.004166595],"study_design_scores_gemma":[0.00007245295,0.0005783463,0.03755979,0.00002088128,0.00006365708,0.0002356428,0.000258485,0.0007387098,0.9534124,0.0003804505,0.00666443,0.00001482942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901619,0.002698904,0.001787456,0.0002970563,0.0001026067,0.00003366928,0.0005033573,0.00007702185,0.004338129],"genre_scores_gemma":[0.9908633,0.002664047,0.000819549,0.0001313524,0.00002089661,0.00003525609,0.0005467656,0.00001826344,0.004900576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003372655,"threshold_uncertainty_score":0.007828832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004867979854961979,"score_gpt":0.2654480605617114,"score_spread":0.2605800807067495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}