{"id":"W2781931068","doi":"10.1126/scitranslmed.aam7577","title":"Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade","year":2018,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":377,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"Brain Tumour Charity; Rosetrees Trust; National Cancer Institute; National Institute for Health and Care Research; Cancer Research UK","keywords":"Oncolytic virus; Blockade; Cytotoxic T cell; Medicine; Infiltration (HVAC); Immunology; Cancer research; Virology; Biology; Virus; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009646844,0.0001208008,0.0001635405,0.0001474461,0.0001485136,0.000007224468,0.0004295099,0.00004173743,0.00006760952],"category_scores_gemma":[0.0004624932,0.00009450874,0.00004924061,0.000373473,0.001351828,0.000007457058,0.00003922124,0.00006016874,0.000007880106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000514997,"about_ca_system_score_gemma":0.0007835726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003157551,"about_ca_topic_score_gemma":0.0000751766,"domain_scores_codex":[0.9983708,0.00003433111,0.0003143928,0.0003901549,0.0005590316,0.0003313192],"domain_scores_gemma":[0.998802,0.00005108369,0.00007583346,0.0002532967,0.0006752788,0.0001425068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001871445,0.0001056037,0.0003752913,0.00001256827,0.00001656843,4.955076e-7,0.0004107473,0.00007105543,0.9903464,0.00009349771,0.00005039314,0.006645914],"study_design_scores_gemma":[0.001846299,0.01543218,0.0224042,0.00005342909,0.000009402263,0.000003263241,0.00005609075,0.00006776426,0.958252,0.0007517413,0.000994059,0.0001295668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938739,0.0002031789,0.00184968,0.003010763,0.00015283,0.0006761563,0.00002773404,0.000007528257,0.0001982513],"genre_scores_gemma":[0.9966232,0.0000114598,0.002248767,0.0007132211,0.0002685716,0.00003922433,0.00003919534,0.00001065341,0.00004569766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03209442,"threshold_uncertainty_score":0.4980865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02485295387765394,"score_gpt":0.3260394576669396,"score_spread":0.3011865037892856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}