{"id":"W2781988148","doi":"10.1042/bsr20171666","title":"The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation","year":2018,"lang":"en","type":"article","venue":"Bioscience Reports","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Terry Fox Foundation; New York University Abu Dhabi; Fondation pour la Recherche Médicale; York University; Al Jalila Foundation","keywords":"Hexokinase; Biochemistry; Isozyme; Mitochondrion; Mutant; Glycolysis; Enzyme; Chemistry; Flux (metallurgy); Biology; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008412806,0.0002101278,0.00009226843,0.00007254611,0.00008068938,0.0001447159,0.0001971324,0.0001373702,0.0004891616],"category_scores_gemma":[0.0001330405,0.00009454111,0.0001847992,0.0001446164,0.000130703,0.0001715084,0.0001208619,0.0002882542,0.0001443521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002110003,"about_ca_system_score_gemma":0.0001341331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008815096,"about_ca_topic_score_gemma":0.0006393833,"domain_scores_codex":[0.9999419,0.000006353201,0.000004493312,0.00001751901,0.00002103874,0.000008674609],"domain_scores_gemma":[0.9999356,0.000006669253,0.00002875593,0.000006898224,0.00001093206,0.00001108648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000206773,0.0000255846,0.001515873,0.00005686984,0.00001073452,0.0001400508,0.00002501716,0.0003073885,0.9940977,0.000227893,0.0001505692,0.00323552],"study_design_scores_gemma":[0.00001740714,0.0001992798,0.03183035,0.00001084677,0.00002618475,0.00132871,0.00005423047,0.004108304,0.9539063,0.0001994268,0.008303831,0.0000152308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992993,0.002376116,0.003217851,0.0001329497,0.00004382533,0.00001025749,0.0003628547,0.00002218715,0.0008410175],"genre_scores_gemma":[0.9952757,0.0008284181,0.001086082,0.00004927582,0.00001221747,0.000007773773,0.001215484,0.000008519358,0.001516391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008815096,"threshold_uncertainty_score":0.001752734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007507012149191806,"score_gpt":0.2467665841451419,"score_spread":0.2392595719959501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}