{"id":"W2782030629","doi":"10.18632/oncotarget.24009","title":"Targeting intracellular B2 receptors using novel cell-penetrating antagonists to arrest growth and induce apoptosis in human triple-negative breast cancer","year":2018,"lang":"en","type":"article","venue":"Oncotarget","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Intracrine; Triple-negative breast cancer; Cancer research; Cell growth; Intracellular; Receptor; G protein-coupled receptor; Apoptosis; Cancer cell; Biology; Cell culture; Medicine; Cancer; Cell biology; Signal transduction; Breast cancer; Paracrine signalling; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000379875,0.0003304666,0.00048655,0.0002528637,0.0003836761,0.00007542122,0.0001204063,0.0001692974,0.000285944],"category_scores_gemma":[0.0001548681,0.00032873,0.00006841688,0.0006238129,0.0001639677,0.0002483474,0.00008983062,0.0002803746,0.000009053841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002244765,"about_ca_system_score_gemma":0.0001896799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005100371,"about_ca_topic_score_gemma":0.0003266802,"domain_scores_codex":[0.9978843,0.00006269983,0.0005784255,0.0005979619,0.0003168581,0.0005597451],"domain_scores_gemma":[0.9989887,0.00008774868,0.0002317183,0.0002001534,0.0001830149,0.0003086101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001205381,0.0001652365,0.3807827,0.00007486119,0.00003179691,0.00000485157,0.003256612,0.00002625481,0.6145957,0.0001233168,0.0004581832,0.0003600087],"study_design_scores_gemma":[0.005368662,0.000575053,0.3315523,0.001315088,0.0001706338,0.00003818017,0.0022483,0.0035167,0.6525819,0.0001994062,0.001322335,0.001111434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964088,0.0004109632,0.0003298577,0.0008740599,0.000707194,0.000598536,0.0000403176,0.00006086829,0.0005693596],"genre_scores_gemma":[0.9881461,0.00005475433,0.009668135,0.0004650728,0.001321688,0.00002682439,0.00004568565,0.00006370983,0.0002079991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04923039,"threshold_uncertainty_score":0.9999165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02213832222744785,"score_gpt":0.2955449291216097,"score_spread":0.2734066068941619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}