{"id":"W2782030629","doi":"10.18632/oncotarget.24009","title":"Targeting intracellular B2 receptors using novel cell-penetrating antagonists to arrest growth and induce apoptosis in human triple-negative breast cancer","year":2018,"lang":"en","type":"article","venue":"Oncotarget","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Intracrine; Triple-negative breast cancer; Cancer research; Cell growth; Intracellular; Receptor; G protein-coupled receptor; Apoptosis; Cancer cell; Biology; Cell culture; Medicine; Cancer; Cell biology; Signal transduction; Breast cancer; Paracrine signalling; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001219109,0.0002465199,0.000421538,0.0001717855,0.0001746272,0.0004406527,0.0001898202,0.000281438,0.001151378],"category_scores_gemma":[0.00009471788,0.0001258422,0.0002135456,0.0002096831,0.0001088726,0.0001621654,0.0001498654,0.0005446725,0.0004762069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003274419,"about_ca_system_score_gemma":0.0002438512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001034842,"about_ca_topic_score_gemma":0.001765013,"domain_scores_codex":[0.999893,0.00001655716,0.000006137663,0.00001547587,0.00002716859,0.00004171108],"domain_scores_gemma":[0.9999808,0.000003150318,0.000003410489,0.000003115749,0.000004392297,0.000005034487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006261346,0.0001644752,0.0002974956,0.00009505776,0.00002135631,0.0001414251,0.00005460056,0.0002601339,0.9839432,0.0001854516,0.0007882827,0.01342243],"study_design_scores_gemma":[0.0005152073,0.00375918,0.007364815,0.00003259762,0.0001269538,0.001810547,0.0001883191,0.003448418,0.9573193,0.0001661086,0.02524622,0.00002235109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797401,0.01371801,0.001911326,0.0004093054,0.0001215106,0.00006728768,0.0002641088,0.0001134711,0.003654958],"genre_scores_gemma":[0.9895264,0.00521682,0.001763155,0.0001623578,0.00002319639,0.0000677438,0.000421449,0.00002610989,0.002792663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001151378,"threshold_uncertainty_score":0.003851771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02213832222744785,"score_gpt":0.2955449291216097,"score_spread":0.2734066068941619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}