{"id":"W2782133571","doi":"10.1021/acs.molpharmaceut.7b01119","title":"Engineered Cellular Uptake and Controlled Drug Delivery Using Two Dimensional Nanoparticle and Polymer for Cancer Treatment","year":2018,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Layered Double Hydroxides Synthesis and Applications","field":"Materials Science","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Science and Engineering Research Board; University Grants Commission","keywords":"Nanoparticle; Drug delivery; Drug; Nanotechnology; Polymer; Cancer; Drug carrier; Chemistry; Cancer cell; Pharmacology; Materials science; Medicine; Organic chemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001149321,0.000155132,0.0002175448,0.00003072562,0.0002084522,0.00006368375,0.00006044044,0.00002823009,0.00007244279],"category_scores_gemma":[0.000007386083,0.0001282662,0.00005030389,0.00005427893,0.0001188719,0.00005260271,0.00004480784,0.00002455006,0.000004417245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000478244,"about_ca_system_score_gemma":0.00004682019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001014674,"about_ca_topic_score_gemma":0.00001095396,"domain_scores_codex":[0.9991001,0.00003500214,0.0001945968,0.0002765517,0.0001142243,0.0002794709],"domain_scores_gemma":[0.999509,0.00007253866,0.00006254651,0.000146087,0.00006578957,0.0001440071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001100385,0.00006569691,0.00002192461,0.00001154595,0.00004908452,0.000004271393,0.0001098987,0.0002849365,0.9965898,0.0004118696,0.000008802323,0.002332122],"study_design_scores_gemma":[0.003655257,0.00003119431,0.000005625242,0.0000113634,0.0002477007,0.000005864938,0.00001077473,0.09453879,0.899151,0.00008590038,0.002119035,0.0001374531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924559,0.005388319,0.001096957,0.0002579075,0.0001338955,0.000560712,0.00004699038,0.0000333789,0.00002592977],"genre_scores_gemma":[0.9964795,0.00006118004,0.002779441,0.0003018363,0.00009665314,0.0001572598,0.000002821861,0.00002404342,0.00009732487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09743877,"threshold_uncertainty_score":0.5230545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03828689678678609,"score_gpt":0.3191352880414485,"score_spread":0.2808483912546624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}