{"id":"W2782174867","doi":"10.1021/acs.jnatprod.7b00680","title":"Serpulanines A to C, N-Oxidized Tyrosine Derivatives Isolated from the Sri Lankan Fungus <i>Serpula</i> sp.: Structure Elucidation, Synthesis, and Histone Deacetylase Inhibition","year":2018,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Research Council Sri Lanka","keywords":"Moiety; Stereochemistry; Hydroxamic acid; Histone deacetylase; Chemistry; Histone deacetylase inhibitor; Biochemistry; Histone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005572806,0.0003073656,0.0005625164,0.000162718,0.0002381472,0.00008668707,0.0001744676,0.0001535518,0.0001185267],"category_scores_gemma":[0.004180947,0.0001683783,0.00008903008,0.0006188182,0.0001936723,0.0003439684,0.00008693522,0.0005956455,0.00001305255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009775777,"about_ca_system_score_gemma":0.0001286026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000780421,"about_ca_topic_score_gemma":0.00006322788,"domain_scores_codex":[0.9980419,0.0001918086,0.0006239639,0.0004292637,0.0004265012,0.0002866129],"domain_scores_gemma":[0.9972205,0.0002039176,0.0005221343,0.0003695669,0.001524119,0.0001598095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002678253,0.000064368,0.0002180296,0.00004636474,0.0001518377,0.00003337862,0.000718076,4.474738e-7,0.9692048,0.00001499869,0.02204001,0.004829389],"study_design_scores_gemma":[0.0009522272,0.0004497743,0.01828921,0.0004729585,0.0003135966,0.0007066141,0.000132517,0.00001059019,0.9597443,0.00008473628,0.01861293,0.0002305813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9421751,0.00602937,0.000007962203,0.05041437,0.0007821944,0.0004828697,0.00005800054,0.00002529813,0.00002478903],"genre_scores_gemma":[0.9893094,0.0001963077,0.004586075,0.002184429,0.003486872,5.540654e-7,0.00003634457,0.00001983207,0.0001802451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04822994,"threshold_uncertainty_score":0.6866267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01016394432752548,"score_gpt":0.252450932259867,"score_spread":0.2422869879323415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}