{"id":"W2782256918","doi":"10.1016/s2468-1253(17)30404-1","title":"Sofosbuvir and velpatasvir for hepatitis C virus infection in people with recent injection drug use (SIMPLIFY): an open-label, single-arm, phase 4, multicentre trial","year":2018,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":292,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; Regent Park Community Health Centre; Ottawa Hospital; Centre Hospitalier de l’Université de Montréal; Vancouver Infectious Diseases Centre","funders":"National Institute on Drug Abuse; National Health and Medical Research Council; Medical Research Council; National Institutes of Health; University of New South Wales; Department of Health and Ageing, Australian Government; Australian Government; Gilead Sciences","keywords":"Medicine; Sofosbuvir; Clinical endpoint; Hepatitis C virus; Internal medicine; Hepatitis C; Adverse effect; Cirrhosis; Clinical trial; Ribavirin; Immunology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001036391,0.0004161649,0.001199661,0.0003766361,0.0003746414,0.0001328242,0.0003848633,0.0003051973,0.0001095257],"category_scores_gemma":[0.0003865822,0.000335877,0.00004561333,0.0003921279,0.0007542439,0.0005583969,0.0003197959,0.0007663738,0.00002481452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003814584,"about_ca_system_score_gemma":0.0002181143,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01876122,"about_ca_topic_score_gemma":0.5754889,"domain_scores_codex":[0.9955167,0.001179397,0.0007358027,0.0009767665,0.0002823806,0.001308944],"domain_scores_gemma":[0.9977579,0.0003573786,0.0003170696,0.0008294468,0.0004169502,0.0003213002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1562024,0.00390088,0.8172363,0.00005214437,0.0001585562,0.00007118986,0.0006510665,0.000002968403,0.002286106,0.00001899638,0.002910463,0.01650895],"study_design_scores_gemma":[0.452999,0.1534939,0.3125517,0.0001727273,0.0005079646,0.001407357,0.0001490992,0.02204857,0.001629249,0.0001901336,0.05420446,0.0006458806],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893646,0.00004467638,0.002661132,0.002711531,0.0007439353,0.004122249,0.0001796383,0.0001106302,0.00006167174],"genre_scores_gemma":[0.9918075,0.00109667,0.001286041,0.003635174,0.0008054276,0.0009189839,0.0003071506,0.0000826649,0.00006042553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5567276,"threshold_uncertainty_score":0.9999093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08690835530574768,"score_gpt":0.3753230150280207,"score_spread":0.288414659722273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}