{"id":"W2782256918","doi":"10.1016/s2468-1253(17)30404-1","title":"Sofosbuvir and velpatasvir for hepatitis C virus infection in people with recent injection drug use (SIMPLIFY): an open-label, single-arm, phase 4, multicentre trial","year":2018,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":292,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; Regent Park Community Health Centre; Ottawa Hospital; Centre Hospitalier de l’Université de Montréal; Vancouver Infectious Diseases Centre","funders":"National Institute on Drug Abuse; National Health and Medical Research Council; Medical Research Council; National Institutes of Health; University of New South Wales; Department of Health and Ageing, Australian Government; Australian Government; Gilead Sciences","keywords":"Medicine; Sofosbuvir; Clinical endpoint; Hepatitis C virus; Internal medicine; Hepatitis C; Adverse effect; Cirrhosis; Clinical trial; Ribavirin; Immunology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001700097,0.00113222,0.001882464,0.0003288143,0.0002636002,0.0008192226,0.0005478018,0.001238738,0.00434549],"category_scores_gemma":[0.00208178,0.0004751452,0.002379324,0.0003195751,0.0007243213,0.00079059,0.0005710266,0.0016399,0.0004685627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005449932,"about_ca_system_score_gemma":0.0007488967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006981372,"about_ca_topic_score_gemma":0.001462459,"domain_scores_codex":[0.9993805,0.0003400786,0.00004457054,0.00008586095,0.00004885165,0.0001001749],"domain_scores_gemma":[0.9992468,0.0002683808,0.0001885693,0.00007343459,0.0000467015,0.0001761076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9626282,0.002655839,0.001736636,0.0009201269,0.002425318,0.00006782346,0.00008020241,0.0004814313,0.001794685,0.0001804379,0.0008641353,0.02616511],"study_design_scores_gemma":[0.957168,0.03675291,0.003405114,0.00004719734,0.001129462,0.00005809869,0.00002287535,0.0002875917,0.0002180348,0.0001485532,0.0007481027,0.00001402176],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885915,0.006323024,0.0003126979,0.000551977,0.0002317307,0.001451113,0.0007243385,0.00005965048,0.001753895],"genre_scores_gemma":[0.9884415,0.003569966,0.001410894,0.0008888942,0.0003708881,0.002040073,0.001179091,0.0000153106,0.002083481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00434549,"threshold_uncertainty_score":0.0145371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08690835530574768,"score_gpt":0.3753230150280207,"score_spread":0.288414659722273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}