{"id":"W2782260459","doi":"10.1186/s40478-017-0506-9","title":"Surfen, a proteoglycan binding agent, reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis","year":2018,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie University; Natural Sciences and Engineering Research Council of Canada; Dalhousie Medical Research Foundation","keywords":"Remyelination; Versican; Experimental autoimmune encephalomyelitis; Aggrecan; CCL5; Chondroitin sulfate proteoglycan; Proteoglycan; Immunology; Chemokine; Chemistry; Inflammation; Cell biology; CCL2; Syndecan 1; Molecular biology; Biology; Immune system; Myelin; Central nervous system; Medicine; T cell; Endocrinology; Biochemistry; Cell; Pathology; Extracellular matrix","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006985397,0.0001785201,0.0002011205,0.0002464375,0.0002635253,0.00003547114,0.0009546044,0.0001570439,0.00001094236],"category_scores_gemma":[0.0008249363,0.0001723272,0.0000719716,0.0005037552,0.0004612597,0.00003679828,0.0008344376,0.0002484638,0.000008164746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003330719,"about_ca_system_score_gemma":0.00009259003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001173628,"about_ca_topic_score_gemma":0.0004005557,"domain_scores_codex":[0.9980262,0.0005492191,0.0005066215,0.0003991215,0.0002139003,0.0003049655],"domain_scores_gemma":[0.9978546,0.0000729772,0.0002563369,0.001381235,0.0003633341,0.0000715093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001028963,0.0001522327,0.001919094,0.00001417723,0.000007492339,0.000001793874,0.0001892779,0.00005073526,0.9920558,0.0001171915,0.00005373172,0.005335608],"study_design_scores_gemma":[0.0007632776,0.0005863437,0.01943551,0.0000886862,0.000009270153,0.00001804013,0.0001391944,0.004908991,0.9722672,0.0002095486,0.001346052,0.0002279404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956579,0.0001521454,0.0004941975,0.001154005,0.00003924612,0.0007773602,0.00006184713,0.00002845518,0.001634876],"genre_scores_gemma":[0.9936323,0.001319531,0.004276729,0.00004162219,0.00007565854,0.0002344303,0.0002424101,0.00002557299,0.0001517151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01978862,"threshold_uncertainty_score":0.7027299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1041443987237225,"score_gpt":0.303127321348082,"score_spread":0.1989829226243595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}