{"id":"W2782297997","doi":"10.1182/blood.v130.suppl_1.lba-2.lba-2","title":"Venetoclax Plus Rituximab Is Superior to Bendamustine Plus Rituximab in Patients with Relapsed/ Refractory Chronic Lymphocytic Leukemia - Results from Pre-Planned Interim Analysis of the Randomized Phase 3 Murano Study","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Jewish General Hospital","funders":"","keywords":"Rituximab; Bendamustine; Medicine; Chemoimmunotherapy; Tumor lysis syndrome; Internal medicine; Interim analysis; Venetoclax; Neutropenia; Gastroenterology; Refractory (planetary science); Obinutuzumab; Chronic lymphocytic leukemia; Oncology; Randomized controlled trial; Leukemia; Chemotherapy; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001264299,0.0005956055,0.002957206,0.000675168,0.0003240311,0.0001284101,0.001338958,0.0002610761,0.0001989454],"category_scores_gemma":[0.002598526,0.0003956452,0.0005101319,0.0009655778,0.0005940861,0.0002484405,0.0007134111,0.0005907123,0.00004123873],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.06721465,"about_ca_system_score_gemma":0.03205873,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04490723,"about_ca_topic_score_gemma":0.005105796,"domain_scores_codex":[0.9941047,0.0005159149,0.001595754,0.001243606,0.001678173,0.0008618556],"domain_scores_gemma":[0.9938636,0.0007450938,0.000792964,0.003815613,0.000400663,0.0003820202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9475436,0.009267274,0.007924885,0.0003234217,0.01211032,0.0006638994,0.016807,0.002513136,0.0008976817,0.000002823565,0.0003500288,0.001595938],"study_design_scores_gemma":[0.9094633,0.00341513,0.03920979,0.0007974527,0.006961476,0.000009469044,0.0002998773,0.03715303,0.002192086,0.000003549179,0.00009873497,0.0003960717],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928423,0.0003312825,0.00001529882,0.00009503268,0.0001934462,0.005350155,0.0008185738,0.0000574374,0.0002965396],"genre_scores_gemma":[0.9982821,0.00003787625,0.0001676565,0.0001097658,0.0001522906,0.0003066999,0.0003189222,0.00009004241,0.0005345879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03980144,"threshold_uncertainty_score":0.9998496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0174912156410489,"score_gpt":0.3097108761363592,"score_spread":0.2922196604953103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}