{"id":"W2782297997","doi":"10.1182/blood.v130.suppl_1.lba-2.lba-2","title":"Venetoclax Plus Rituximab Is Superior to Bendamustine Plus Rituximab in Patients with Relapsed/ Refractory Chronic Lymphocytic Leukemia - Results from Pre-Planned Interim Analysis of the Randomized Phase 3 Murano Study","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Jewish General Hospital","funders":"","keywords":"Rituximab; Bendamustine; Medicine; Chemoimmunotherapy; Tumor lysis syndrome; Internal medicine; Interim analysis; Venetoclax; Neutropenia; Gastroenterology; Refractory (planetary science); Obinutuzumab; Chronic lymphocytic leukemia; Oncology; Randomized controlled trial; Leukemia; Chemotherapy; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006296363,0.001104347,0.002981568,0.0003469316,0.0003271452,0.001382306,0.0008917429,0.001201519,0.003635116],"category_scores_gemma":[0.003182298,0.0005315416,0.003523408,0.0003584841,0.0009313985,0.001086011,0.000508983,0.002671623,0.0007092546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000890239,"about_ca_system_score_gemma":0.001163258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005142121,"about_ca_topic_score_gemma":0.001342368,"domain_scores_codex":[0.9963706,0.002549893,0.0001588976,0.0003781045,0.0001875377,0.0003550204],"domain_scores_gemma":[0.997494,0.0009079293,0.000648658,0.0003264175,0.0001048876,0.0005181387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9720184,0.003933015,0.003231112,0.0002066128,0.001805393,0.00004052601,0.00004922295,0.0003924688,0.0029252,0.00006400956,0.0006263059,0.01470761],"study_design_scores_gemma":[0.6100852,0.3543342,0.02734371,0.00006951043,0.0030402,0.0001046533,0.00005824482,0.001173633,0.001579014,0.0003121578,0.001852853,0.00004661599],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991863,0.003483588,0.0004478765,0.0003188849,0.0001924877,0.001159386,0.001001296,0.00007080869,0.001462748],"genre_scores_gemma":[0.993677,0.0007483336,0.0008275149,0.0005563814,0.0002633304,0.001163266,0.001275308,0.00002400381,0.001464997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006296363,"threshold_uncertainty_score":0.03329879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0174912156410489,"score_gpt":0.3097108761363592,"score_spread":0.2922196604953103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}