{"id":"W2782353569","doi":"10.21769/bioprotoc.2674","title":"Targeted Genome Editing of Virulent Phages Using CRISPR-Cas9","year":2018,"lang":"en","type":"article","venue":"BIO-PROTOCOL","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"CRISPR; Biology; Genome editing; Lytic cycle; Plasmid; Cas9; Genome; Homologous recombination; Virulence; Genetics; Bacteriophage; Lactococcus lactis; Gene; Cre-Lox recombination; Gene targeting; Temperateness; Computational biology; Phagemid; Bacteria; Virus; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005024131,0.0006884056,0.0004574607,0.0004542636,0.0003591188,0.0006021337,0.0006902507,0.0006357736,0.001915064],"category_scores_gemma":[0.0004188127,0.0004323493,0.0004751928,0.0002617585,0.0004075636,0.000297815,0.000921093,0.001287266,0.0009360058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004731746,"about_ca_system_score_gemma":0.0005054525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007160945,"about_ca_topic_score_gemma":0.001401398,"domain_scores_codex":[0.9994658,0.00007117481,0.00006756745,0.0001324419,0.0001695732,0.00009355698],"domain_scores_gemma":[0.999676,0.00008125849,0.00007632816,0.00006655251,0.00003201708,0.0000678399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004676239,0.00002273562,0.00009191176,0.00005523745,0.000006229837,0.00008892317,0.00003422893,0.0001352824,0.9971222,0.0004746295,0.0001113689,0.001810571],"study_design_scores_gemma":[0.00001375562,0.00008499648,0.0007152703,0.000009656955,0.00001233469,0.000219151,0.00001709292,0.001248063,0.9889497,0.000130584,0.008586334,0.00001309765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7472774,0.001305131,0.2311283,0.0003481489,0.0003979064,0.000974439,0.003643788,0.003974481,0.01095036],"genre_scores_gemma":[0.8966759,0.0007516837,0.08360504,0.0001530137,0.00001952097,0.0004347071,0.004133041,0.0006466938,0.0135804],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001915064,"threshold_uncertainty_score":0.006406546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02649473446568976,"score_gpt":0.3272003385640268,"score_spread":0.300705604098337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}