{"id":"W2782375341","doi":"10.1038/s41598-017-18547-9","title":"Protein tyrosine kinase, PtkA, is required for Mycobacterium tuberculosis growth in macrophages","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; British Columbia Centre for Disease Control","keywords":"Protein tyrosine phosphatase; Biology; Mutant; Phosphorylation; Mycobacterium tuberculosis; Operon; Tyrosine phosphorylation; Kinase; Protein kinase A; Macrophage; Cell biology; Phagosome; Tyrosine kinase; Tyrosine; Microbiology; Intracellular; Biochemistry; Signal transduction; In vitro; Gene; Tuberculosis; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003042187,0.0002336436,0.0005428224,0.000473564,0.0002710832,0.0001176839,0.0001435154,0.0001861432,0.0005251581],"category_scores_gemma":[0.002748715,0.0001894672,0.0002025507,0.0009106943,0.0007462664,0.0002136347,0.0001220341,0.0001939437,0.0001330492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001598389,"about_ca_system_score_gemma":0.0002707926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003239778,"about_ca_topic_score_gemma":0.0001056398,"domain_scores_codex":[0.9963653,0.0001116026,0.0008617879,0.001199507,0.0005172031,0.0009445912],"domain_scores_gemma":[0.9976368,0.00007701177,0.0002147691,0.0009877419,0.0007165126,0.0003671974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003491905,0.0002871518,0.04990467,0.0003357756,0.00006194811,0.0006433019,0.0002949611,2.249414e-7,0.7558644,0.0001464542,0.1898127,0.002299185],"study_design_scores_gemma":[0.001258695,0.0009311424,0.06582797,0.0003870966,0.00006084327,0.0005742295,0.00007036603,0.0003590018,0.8154286,0.008629063,0.1060903,0.0003827442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984377,0.0003664973,0.0001090956,0.008614034,0.002291393,0.001833749,0.00002119999,0.00008365598,0.002303339],"genre_scores_gemma":[0.9855017,0.0000192162,0.002355749,0.000679337,0.0004948699,0.0003554238,0.0001540003,0.00003790694,0.01040176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08372241,"threshold_uncertainty_score":0.772625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02942492325285935,"score_gpt":0.3222783191703136,"score_spread":0.2928533959174543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}