{"id":"W2782399000","doi":"10.1038/s41380-017-0004-2","title":"Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia","year":2018,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"ZonMw; Stanley Center for Psychiatric Research, Broad Institute; Universidad de Costa Rica; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Broad Institute; European Commission; University of Texas Health Science Center at San Antonio; Sylvan C. Herman Foundation; Stichting ParkinsonFonds; National Institute of Mental Health; National Heart, Lung, and Blood Institute; Vetenskapsrådet; Stanley Medical Research Institute","keywords":"Induced pluripotent stem cell; Biology; Mutation; Missense mutation; Oligodendrocyte; Genetics; Population; Neuroscience; Medicine; Embryonic stem cell; Gene; Myelin; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000138101,0.0002359352,0.0001580176,0.0001261791,0.000143583,0.00005032764,0.0001379629,0.0002017032,0.000003273998],"category_scores_gemma":[0.000005079068,0.0002537965,0.00007838771,0.0001743308,0.00004745979,0.000008444405,0.00009584434,0.0001509502,0.00001396369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002576414,"about_ca_system_score_gemma":0.0001563582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001096194,"about_ca_topic_score_gemma":0.0003304121,"domain_scores_codex":[0.9985026,0.00008774247,0.0003460775,0.0005776204,0.000164739,0.0003212187],"domain_scores_gemma":[0.9992695,0.000003045828,0.0001080516,0.000384915,0.0001046539,0.0001298687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001587573,0.00009253436,0.00294009,0.00003348265,0.000019193,0.000002792049,0.00006728575,0.001000284,0.9937549,0.00003826376,0.00001290288,0.001879561],"study_design_scores_gemma":[0.002179238,0.0005580158,0.001794992,0.00002081082,0.00005159729,0.000007220077,0.0001802773,0.009251295,0.9847651,0.000482916,0.0003000733,0.0004085074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979852,0.002608671,0.01600362,0.0000935681,0.0005590993,0.000374606,0.00001695289,0.00002046272,0.0004710231],"genre_scores_gemma":[0.9962726,0.0001383929,0.002892597,0.00009068843,0.0003390355,0.00005458115,0.00009810585,0.00004821826,0.00006581863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01642057,"threshold_uncertainty_score":0.9999914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008545520112680342,"score_gpt":0.2353602621228976,"score_spread":0.2268147420102173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}