{"id":"W2782412954","doi":"","title":"Abstract 19780: ABCA1 Response to Atherogenic Lipid Exposure is Reduced in Cultured Human Aortic Smooth Muscle Cells Compared to Human Monocyte-Derived Macrophages","year":2016,"lang":"en","type":"article","venue":"Circulation","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"ABCA1; Foam cell; Cholesterol; Cholesteryl ester; Lipoprotein; Apolipoprotein B; Endocrinology; Internal medicine; Monocyte; Downregulation and upregulation; Medicine; Tangier disease; High-density lipoprotein; Low-density lipoprotein; Biology; Biochemistry; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002798668,0.0003272909,0.0003792453,0.000252704,0.0002153168,0.0003130181,0.0001581579,0.0003266665,0.00552176],"category_scores_gemma":[0.0001990445,0.0001875585,0.0002725966,0.0003578071,0.0001858492,0.0001339074,0.0002455789,0.0004997391,0.002392918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002400242,"about_ca_system_score_gemma":0.000194651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001586001,"about_ca_topic_score_gemma":0.001265396,"domain_scores_codex":[0.9994785,0.00008879969,0.00005944175,0.00008646202,0.0001818255,0.0001050066],"domain_scores_gemma":[0.9998327,0.00003417458,0.00001768133,0.00002492248,0.00006304578,0.0000274164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000258713,0.00004437227,0.0003628331,0.00005297423,0.000008968863,0.00006399339,0.00003135406,0.00001082366,0.9978738,0.00001749002,0.0001810314,0.001093644],"study_design_scores_gemma":[0.00006310064,0.001263254,0.03721514,0.00002109672,0.00004630334,0.0006172813,0.0001318768,0.0004895168,0.9520966,0.00003622767,0.008010229,0.000009288882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842775,0.004809442,0.002789499,0.0004505443,0.0002087829,0.00009742603,0.002694828,0.0001415914,0.004530472],"genre_scores_gemma":[0.9565223,0.002727362,0.005254607,0.000482105,0.0001237964,0.0003921514,0.01162014,0.00005700651,0.02282045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00552176,"threshold_uncertainty_score":0.01847219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03102644077636054,"score_gpt":0.3010997575947508,"score_spread":0.2700733168183903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}