{"id":"W2782427095","doi":"10.3389/fphar.2017.00924","title":"Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and ΔFosB","year":2018,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"National Institute on Drug Abuse; National Institutes of Health","keywords":"Nucleus accumbens; Dopamine; Dopamine receptor D2; Conditioned place preference; FOSB; Pharmacology; Chemistry; Striatum; Brain stimulation reward; Dopamine receptor; Neuroscience; Dopamine receptor D1; Dopamine receptor D3; Addiction; Biology; Biochemistry; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001044212,0.000284458,0.0002897495,0.00009860397,0.0001003439,0.0002184465,0.0001920555,0.0001692567,0.001134348],"category_scores_gemma":[0.00008953886,0.0001180436,0.0001673533,0.00007378296,0.0002171461,0.0001569004,0.0001237074,0.0006269134,0.0002079961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002387349,"about_ca_system_score_gemma":0.0002418841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007083612,"about_ca_topic_score_gemma":0.001623357,"domain_scores_codex":[0.9998809,0.00001646883,0.00001210393,0.00002562309,0.00002463911,0.00004020186],"domain_scores_gemma":[0.9999415,0.000006032816,0.00001372684,0.00000604068,0.000005083766,0.00002759011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003044413,0.0000475579,0.0001251073,0.00002718257,0.000007809938,0.00002245091,0.000009187923,0.00004386436,0.9988613,0.00005785779,0.0000332192,0.0004598621],"study_design_scores_gemma":[0.00004873267,0.000635934,0.006540991,0.000005156804,0.00002479937,0.0001578556,0.0000479943,0.001906297,0.9893005,0.00004351703,0.001282919,0.000005355921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979551,0.0005484987,0.0007039529,0.0000636629,0.00001864421,0.000009755306,0.0001473394,0.00002736877,0.0005256419],"genre_scores_gemma":[0.9974951,0.0003687556,0.0005116475,0.00003505676,0.000006655323,0.00002387884,0.0001775932,0.000008647063,0.001372781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001134348,"threshold_uncertainty_score":0.00379473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.045603249421173,"score_gpt":0.3263076526444054,"score_spread":0.2807044032232324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}