{"id":"W2782537156","doi":"10.3390/v10010013","title":"Regulation of CD4 Receptor and HIV-1 Entry by MicroRNAs-221 and -222 during Differentiation of THP-1 Cells","year":2017,"lang":"en","type":"article","venue":"Viruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"THP1 cell line; Biology; Chemokine receptor; Cell culture; Monocyte; Chemokine; Receptor; microRNA; Cellular differentiation; Macrophage; Viral entry; Virus; Cell biology; Viral replication; CXCR4; Cell type; Virology; Immunology; Cell; Genetics; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001787186,0.000187675,0.0002854292,0.0001643133,0.0002820198,0.0003749077,0.0001656174,0.0001803992,0.0008077191],"category_scores_gemma":[0.000149789,0.0001862528,0.0002225736,0.0001865076,0.0002268181,0.0001463798,0.0002251307,0.0005043249,0.0006581904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002964307,"about_ca_system_score_gemma":0.0002647054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005073964,"about_ca_topic_score_gemma":0.0007568319,"domain_scores_codex":[0.999669,0.00006513789,0.00004152846,0.00005526158,0.00009661312,0.00007251905],"domain_scores_gemma":[0.9998884,0.00002062072,0.00002619237,0.00001691591,0.00002869584,0.00001906992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008134281,0.00001161498,0.0001855661,0.00002933271,0.000002482466,0.0000356381,0.00003585063,0.0000295273,0.9989416,0.00008033344,0.00004066177,0.0005260268],"study_design_scores_gemma":[0.00001293585,0.000138218,0.00508511,0.000005811702,0.00001471248,0.0002492208,0.00006594298,0.000720114,0.9893081,0.0000390089,0.004351133,0.000009592473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872482,0.002113415,0.006231334,0.0001310306,0.00008134585,0.00008594129,0.001254822,0.00007478531,0.002779049],"genre_scores_gemma":[0.9734077,0.001714351,0.0178801,0.0001431724,0.00002893811,0.0001723718,0.001709693,0.0000356904,0.004907948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008077191,"threshold_uncertainty_score":0.002702117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01296451373975204,"score_gpt":0.2466100706732365,"score_spread":0.2336455569334844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}