{"id":"W2782537156","doi":"10.3390/v10010013","title":"Regulation of CD4 Receptor and HIV-1 Entry by MicroRNAs-221 and -222 during Differentiation of THP-1 Cells","year":2017,"lang":"en","type":"article","venue":"Viruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"THP1 cell line; Biology; Chemokine receptor; Cell culture; Monocyte; Chemokine; Receptor; microRNA; Cellular differentiation; Macrophage; Viral entry; Virus; Cell biology; Viral replication; CXCR4; Cell type; Virology; Immunology; Cell; Genetics; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004566293,0.00006733323,0.0001334385,0.00003950454,0.0001477884,0.00001251482,0.0000606674,0.00007326408,0.000165138],"category_scores_gemma":[0.00002735101,0.00005539673,0.00001832106,0.00001100596,0.0001882957,0.0000903326,0.00006435427,0.00004703489,0.0000421334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008309243,"about_ca_system_score_gemma":0.000008693333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00013676,"about_ca_topic_score_gemma":0.00001565177,"domain_scores_codex":[0.9995742,0.00004948934,0.0001241658,0.0001203495,0.00002269292,0.0001090442],"domain_scores_gemma":[0.9996114,0.00004026865,0.0001396779,0.0001689028,0.0000247865,0.00001500359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001220985,0.0000683844,0.09289416,0.00004153966,0.00007721601,2.082438e-7,0.0001527803,6.274443e-8,0.9037101,0.0000269632,0.001227457,0.001679018],"study_design_scores_gemma":[0.0007975178,0.00004623105,0.290247,0.00002573592,0.00001335908,0.000001175314,0.0000276378,2.71824e-7,0.7073838,0.00001589443,0.001408813,0.00003260667],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974654,0.001827965,0.000009225491,0.00004709173,0.00006453788,0.0001078412,0.000327393,0.000006156108,0.0001443682],"genre_scores_gemma":[0.9980106,0.001075094,0.00003562753,0.000004030841,0.000007342782,0.000004345225,0.00008529543,0.000004931748,0.0007727303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1973528,"threshold_uncertainty_score":0.2259013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01296451373975204,"score_gpt":0.2466100706732365,"score_spread":0.2336455569334844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}