{"id":"W2782573178","doi":"10.1128/mbio.02158-17","title":"Molecular Insights into Function and Competitive Inhibition of <i>Pseudomonas aeruginosa</i> Multiple Virulence Factor Regulator","year":2018,"lang":"en","type":"article","venue":"mBio","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Armand Frappier Museum; Institut National de la Recherche Scientifique","funders":"National Institute of Allergy and Infectious Diseases; Uehara Memorial Foundation","keywords":"Pseudomonas aeruginosa; Allosteric regulation; Quorum sensing; Virulence factor; Drug discovery; Ligand (biochemistry); Chemistry; Regulator; Biochemistry; Biology; Virulence; Bacteria; Genetics; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008888237,0.0003168351,0.0001525484,0.00007463298,0.00007964399,0.0001579498,0.0002454832,0.0002163637,0.001030562],"category_scores_gemma":[0.00007157214,0.00008006304,0.0002476722,0.00003988605,0.0001302771,0.0001219527,0.00009349058,0.0003975474,0.0003772283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003208478,"about_ca_system_score_gemma":0.0001470952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006561233,"about_ca_topic_score_gemma":0.0004990258,"domain_scores_codex":[0.999943,0.00001017438,0.000002802136,0.000009152022,0.00001931056,0.00001549812],"domain_scores_gemma":[0.9999615,0.000007082086,0.00001354025,0.000002712674,0.000005929274,0.00000917284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008514083,0.00002110839,0.0002567313,0.00003385767,0.000003409867,0.00007429806,0.000004520611,0.0001770226,0.9980217,0.0002281846,0.00004197908,0.001051866],"study_design_scores_gemma":[0.00003352145,0.0003961672,0.003187225,0.000009173462,0.00001560587,0.0005493283,0.00002037158,0.004851724,0.9875373,0.0001687137,0.003224286,0.000006552853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901164,0.002760666,0.004641949,0.000294572,0.00002449793,0.00001363505,0.000147624,0.00009978066,0.001900754],"genre_scores_gemma":[0.9963472,0.0007205327,0.001877131,0.00006584912,0.000007658074,0.000006643602,0.0001458237,0.000006201744,0.0008230167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001030562,"threshold_uncertainty_score":0.003447592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005823626653405989,"score_gpt":0.2149581280432032,"score_spread":0.2091345013897972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}