{"id":"W2782651985","doi":"10.1016/j.bbr.2018.01.004","title":"Antidepressant effects of focused ultrasound induced blood-brain-barrier opening","year":2018,"lang":"en","type":"article","venue":"Behavioural Brain Research","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; University of Toronto; Centre for Addiction and Mental Health; Sunnybrook Health Science Centre","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institutes of Health; Canada Research Chairs; Canadian Institutes of Health Research; Lantheus Medical Imaging","keywords":"Antidepressant; Neurogenesis; Behavioural despair test; Hippocampal formation; Ultrasound; Medicine; Blood–brain barrier; Focused ultrasound; Hippocampus; Internal medicine; Neuroscience; Pharmacology; Psychology; Central nervous system; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001183948,0.0003125964,0.0003457923,0.0001866293,0.0001696704,0.0001968495,0.0003098675,0.0004258273,0.005151618],"category_scores_gemma":[0.0003054441,0.000157852,0.0002581705,0.0001616025,0.0003135776,0.0002488075,0.0001269681,0.0007785867,0.0003500518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001987716,"about_ca_system_score_gemma":0.0002373735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001314412,"about_ca_topic_score_gemma":0.002168763,"domain_scores_codex":[0.999928,0.00001841932,0.000004967164,0.00001070364,0.000008779603,0.00002906605],"domain_scores_gemma":[0.9998804,0.00003800166,0.00002070719,0.00001615633,0.00001361013,0.00003111458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01589657,0.0008951323,0.0003365871,0.0002905281,0.00009206502,0.0002217378,0.0001787169,0.0001490766,0.9643724,0.0004584555,0.0004744502,0.01663426],"study_design_scores_gemma":[0.00231297,0.0438949,0.02952207,0.00009016596,0.0004437561,0.0006593874,0.0003266691,0.001454612,0.916654,0.0003872381,0.004211114,0.000043095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994929,0.002019423,0.0005005329,0.0001572141,0.00008958668,0.00005568263,0.0002359795,0.00003433889,0.001978336],"genre_scores_gemma":[0.9953312,0.001678424,0.0004403609,0.000092207,0.00005098219,0.00005350975,0.0001841198,0.000004899639,0.002164263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005151618,"threshold_uncertainty_score":0.01723391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05464881809064091,"score_gpt":0.3289500472059176,"score_spread":0.2743012291152767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}