{"id":"W2782702360","doi":"10.1371/journal.pone.0188453","title":"Construction of an infectious horsepox virus vaccine from chemically synthesized DNA fragments","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Poxvirus research and outbreaks","field":"Immunology and Microbiology","cited_by":295,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Innovates","keywords":"Vaccinia; Virology; Virus; Biology; Smallpox vaccine; DNA vaccination; Poxviridae; Smallpox virus; DNA; Modified vaccinia Ankara; Attenuated vaccine; Virulence; Viral replication; DNA sequencing; Orthopoxvirus; Gene; Recombinant DNA; Genetics; Plasmid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003023585,0.0003857025,0.000270851,0.0002940668,0.0001844394,0.0002956675,0.0004002877,0.0004716413,0.001369399],"category_scores_gemma":[0.0003737497,0.0002597495,0.0004407523,0.0002454004,0.0003673689,0.0002819631,0.0002523255,0.0008515112,0.0006576066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003823176,"about_ca_system_score_gemma":0.0003801182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003589841,"about_ca_topic_score_gemma":0.0004425276,"domain_scores_codex":[0.999843,0.00003499117,0.00001507961,0.00003229806,0.00004360049,0.00003090052],"domain_scores_gemma":[0.9998411,0.00004821396,0.00004463334,0.00001963081,0.00001937933,0.00002697155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004865411,0.000029353,0.0001093771,0.00005982835,0.000006565199,0.00004532693,0.00002752683,0.0004432748,0.9973243,0.0004075733,0.00002154985,0.001476662],"study_design_scores_gemma":[0.00003873386,0.0006446053,0.0007729858,0.00001503664,0.00002712448,0.0001319672,0.00003761917,0.001543444,0.9924394,0.0001791495,0.004160755,0.000009292546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9522759,0.0009102278,0.04255005,0.0001753131,0.00007871706,0.0004974168,0.0007075993,0.0001804323,0.002624335],"genre_scores_gemma":[0.9260864,0.0008378241,0.0647548,0.0001289972,0.00002346914,0.0002683553,0.002853595,0.00008137606,0.004965265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001369399,"threshold_uncertainty_score":0.004581034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01944486651548311,"score_gpt":0.2389879927249767,"score_spread":0.2195431262094936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}