{"id":"W2782702360","doi":"10.1371/journal.pone.0188453","title":"Construction of an infectious horsepox virus vaccine from chemically synthesized DNA fragments","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Poxvirus research and outbreaks","field":"Immunology and Microbiology","cited_by":295,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Innovates","keywords":"Vaccinia; Virology; Virus; Biology; Smallpox vaccine; DNA vaccination; Poxviridae; Smallpox virus; DNA; Modified vaccinia Ankara; Attenuated vaccine; Virulence; Viral replication; DNA sequencing; Orthopoxvirus; Gene; Recombinant DNA; Genetics; Plasmid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001199766,0.0001266794,0.0003275546,0.00008839296,0.00009870608,0.000009048769,0.000191208,0.0002323229,0.003196876],"category_scores_gemma":[0.0002883259,0.0001159712,0.0000470642,0.0001043619,0.0002506528,0.0001056407,0.00007658673,0.000215733,0.0008292226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003127667,"about_ca_system_score_gemma":0.00004824473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000581955,"about_ca_topic_score_gemma":0.0001491547,"domain_scores_codex":[0.9989774,0.0001435697,0.0002569871,0.0002518055,0.00007586288,0.0002943356],"domain_scores_gemma":[0.9992353,0.0001142897,0.0001133638,0.000327214,0.0001592116,0.00005056422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006588939,0.001195241,0.002779356,0.00001263863,0.0006435249,0.000002076485,0.0001024577,1.610123e-8,0.9893124,0.00003199186,0.0001535267,0.005107938],"study_design_scores_gemma":[0.001659652,0.0005135707,0.004050987,0.00006346059,0.00009290007,0.000005666003,0.00002047689,0.000006748277,0.9921138,0.0007376707,0.0006191004,0.0001159182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997139,0.0002615092,0.00003357358,0.00005865664,0.0001205153,0.0001906703,0.0001411729,0.00008263238,0.001972214],"genre_scores_gemma":[0.9985527,0.0001029611,0.000787057,0.000064485,0.0001212608,0.00001689622,0.0001225609,0.00001530183,0.000216784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00499202,"threshold_uncertainty_score":0.9999487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01944486651548311,"score_gpt":0.2389879927249767,"score_spread":0.2195431262094936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}