{"id":"W2782730053","doi":"10.1038/nchembio.2557","title":"Allosteric inhibitors hit USP7 hard","year":2018,"lang":"en","type":"letter","venue":"Nature Chemical Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Allosteric regulation; Chemistry; Drug discovery; Small molecule; Mdm2; Ubiquitin; Drug; Deubiquitinating enzyme; Computational biology; Pharmacology; Enzyme; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0001601828,0.0005904604,0.0005299118,0.00008590815,0.00006356856,0.0000302513,0.0008082529,0.01017445,0.000313705],"category_scores_gemma":[0.0002509816,0.0005098679,0.0003575181,0.0001243187,0.0004619527,0.000002162412,0.0005083406,0.003323228,0.0002660523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004392133,"about_ca_system_score_gemma":0.0001241834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004452741,"about_ca_topic_score_gemma":0.000001324803,"domain_scores_codex":[0.9973192,0.0001521627,0.0003896114,0.001196221,0.0001769643,0.0007658214],"domain_scores_gemma":[0.9986269,0.00004670014,0.0002263249,0.0007935801,0.0001866797,0.0001198294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003350983,0.00001105897,0.00005671332,0.00003927345,0.0000645835,0.00001635222,0.00000370034,4.182996e-9,0.4660889,0.000006909651,0.5330994,0.0005796079],"study_design_scores_gemma":[0.0001973092,0.0001696094,0.000004038533,0.00002027168,0.00002320528,0.00004776934,8.842213e-7,2.597921e-7,0.4292668,0.0002136665,0.5696989,0.0003572379],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.3427001,0.02139513,0.00009783529,0.5911352,0.01062934,0.002007448,0.002209347,0.0003732932,0.02945235],"genre_scores_gemma":[0.05320871,0.0002597546,0.001310985,0.8772541,0.04696772,0.0001280543,0.01601037,0.0001699601,0.004690349],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2894914,"threshold_uncertainty_score":0.9997353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01080577349511801,"score_gpt":0.2516368954305181,"score_spread":0.2408311219354001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}