{"id":"W2782730053","doi":"10.1038/nchembio.2557","title":"Allosteric inhibitors hit USP7 hard","year":2018,"lang":"en","type":"letter","venue":"Nature Chemical Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Allosteric regulation; Chemistry; Drug discovery; Small molecule; Mdm2; Ubiquitin; Drug; Deubiquitinating enzyme; Computational biology; Pharmacology; Enzyme; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001571165,0.0008095603,0.0007789458,0.0003627379,0.001348727,0.001827148,0.0007347027,0.008107699,0.009438768],"category_scores_gemma":[0.004986479,0.0003472888,0.0006861865,0.0002040505,0.001802525,0.001505504,0.001033402,0.01252733,0.00439882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002108964,"about_ca_system_score_gemma":0.0006831178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006221673,"about_ca_topic_score_gemma":0.001383426,"domain_scores_codex":[0.9991998,0.000114402,0.00006211969,0.0001151125,0.0003555199,0.0001530127],"domain_scores_gemma":[0.9988824,0.0005371385,0.00008822235,0.0001245237,0.0001759291,0.0001918233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008056185,0.0001658573,0.0006216978,0.0002077971,0.00006610782,0.003608662,0.00007752639,0.0003623913,0.01233634,0.04257385,0.8768604,0.06231361],"study_design_scores_gemma":[0.0006542238,0.0003813983,0.0005568368,0.00008972765,0.00006084109,0.002112101,0.00009524952,0.001561879,0.02686404,0.04107763,0.926495,0.00005102372],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01220113,0.0170816,0.00315628,0.8687363,0.05496271,0.00007404639,0.000350555,0.0006744178,0.04276298],"genre_scores_gemma":[0.2214856,0.01472009,0.003815258,0.5717995,0.03797811,0.000247984,0.0004059623,0.0002845907,0.1492628],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.009438768,"threshold_uncertainty_score":0.03157586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01080577349511801,"score_gpt":0.2516368954305181,"score_spread":0.2408311219354001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}