{"id":"W2782775245","doi":"10.1007/s10495-018-1440-4","title":"Negative regulators of cell death pathways in cancer: perspective on biomarkers and targeted therapies","year":2018,"lang":"en","type":"review","venue":"APOPTOSIS","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"","keywords":"Necroptosis; Programmed cell death; Autophagy; Cancer; Signal transduction; Cancer cell; FADD; Cancer research; Medicine; Biology; Apoptosis; Caspase; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008416866,0.0008043817,0.001633126,0.001817922,0.0002712105,0.001191812,0.001013886,0.001341444,0.002522625],"category_scores_gemma":[0.001115863,0.0002151444,0.0004986989,0.001618898,0.0007240112,0.001447824,0.0007852079,0.002198342,0.0009446348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007413275,"about_ca_system_score_gemma":0.001167216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007842563,"about_ca_topic_score_gemma":0.001617871,"domain_scores_codex":[0.9997515,0.00004988744,0.0000361058,0.0000443146,0.00009050564,0.0000277396],"domain_scores_gemma":[0.9993733,0.0003395066,0.00007746403,0.0000152818,0.000154139,0.00004034302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001336002,0.00009190943,0.0002893509,0.01959208,0.0001089013,0.0002206061,0.00006775244,0.0004321878,0.002212909,0.007903395,0.03981658,0.9291307],"study_design_scores_gemma":[0.00003117631,0.0001541928,0.0007733512,0.004790378,0.0001727559,0.001095332,0.00008854748,0.0001843448,0.0006480158,0.005773861,0.9862638,0.00002427967],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004707671,0.9989789,0.00008892246,0.000379882,0.0001599015,0.000001874468,0.000009561778,0.000003624821,0.0003303899],"genre_scores_gemma":[0.000618659,0.9983895,0.0001338104,0.0002872577,0.0002720571,0.000003671564,0.00001713766,8.136944e-7,0.0002771923],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002522625,"threshold_uncertainty_score":0.008439004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04777861842517035,"score_gpt":0.3261747301485288,"score_spread":0.2783961117233584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}