{"id":"W2782813959","doi":"10.1080/13625187.2017.1413179","title":"Pharmacokinetic bioequivalence, safety and acceptability of Ornibel®, a new polymer composition contraceptive vaginal ring (etonogestrel/ethinylestradiol 11.00/3.474 mg) compared with Nuvaring® (etonogestrel/ethinylestradiol 11.7/2.7 mg)","year":2017,"lang":"en","type":"article","venue":"The European Journal of Contraception & Reproductive Health Care","topic":"Reproductive Health and Contraception","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Altasciences (Canada)","funders":"European Regional Development Fund; Centro para el Desarrollo Tecnológico Industrial","keywords":"Etonogestrel; Ethinylestradiol; Vaginal ring; Medicine; Desogestrel; Bioequivalence; Cmax; Crossover study; Tolerability; Intravaginal administration; Pharmacokinetics; Population; Pharmacology; Internal medicine; Adverse effect; Vagina; Surgery; Family planning; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001071297,0.0002596363,0.0003971181,0.0001635112,0.00009531961,0.0004273214,0.0001711572,0.0003657425,0.002930729],"category_scores_gemma":[0.001900878,0.0002119605,0.0002904592,0.0001561998,0.0003084474,0.0003676982,0.0001319145,0.0005280662,0.0004520329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003202604,"about_ca_system_score_gemma":0.0002788571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004329393,"about_ca_topic_score_gemma":0.0003273985,"domain_scores_codex":[0.999105,0.0004953397,0.00004653373,0.0001314677,0.000174301,0.00004731289],"domain_scores_gemma":[0.999413,0.000185623,0.0001832506,0.00007087898,0.00005738515,0.00008984929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4861603,0.01795187,0.03770079,0.0009495843,0.001653758,0.0002432227,0.0008465256,0.002732991,0.2653945,0.0006788674,0.001745401,0.1839422],"study_design_scores_gemma":[0.03238368,0.5493492,0.2921242,0.00009718413,0.002067937,0.001648771,0.0005627827,0.009453039,0.09684796,0.0004912028,0.01482787,0.0001462208],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979196,0.0007712835,0.0004292192,0.00003693496,0.00002492893,0.00007078057,0.0001932572,0.0000131879,0.0005406996],"genre_scores_gemma":[0.9975782,0.00034887,0.0004515077,0.00004530445,0.00003111684,0.00009658609,0.0002059971,0.00001139517,0.001230984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002930729,"threshold_uncertainty_score":0.009804249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02725816962532538,"score_gpt":0.3109434997256892,"score_spread":0.2836853301003638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}