{"id":"W2782813959","doi":"10.1080/13625187.2017.1413179","title":"Pharmacokinetic bioequivalence, safety and acceptability of Ornibel®, a new polymer composition contraceptive vaginal ring (etonogestrel/ethinylestradiol 11.00/3.474 mg) compared with Nuvaring® (etonogestrel/ethinylestradiol 11.7/2.7 mg)","year":2017,"lang":"en","type":"article","venue":"The European Journal of Contraception & Reproductive Health Care","topic":"Reproductive Health and Contraception","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Altasciences (Canada)","funders":"European Regional Development Fund; Centro para el Desarrollo Tecnológico Industrial","keywords":"Etonogestrel; Ethinylestradiol; Vaginal ring; Medicine; Desogestrel; Bioequivalence; Cmax; Crossover study; Tolerability; Intravaginal administration; Pharmacokinetics; Population; Pharmacology; Internal medicine; Adverse effect; Vagina; Surgery; Family planning; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.006474787,0.001040404,0.002287912,0.000471251,0.001717705,0.0002452971,0.0009601625,0.0002033448,0.0002098135],"category_scores_gemma":[0.000765831,0.0007961214,0.0004918678,0.0004341291,0.002062838,0.001332158,0.0001851743,0.002335823,0.00001940201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000856571,"about_ca_system_score_gemma":0.001709727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007104076,"about_ca_topic_score_gemma":0.00003917068,"domain_scores_codex":[0.9887183,0.003700671,0.003035347,0.001795189,0.001472618,0.00127786],"domain_scores_gemma":[0.9887353,0.0003762305,0.004606565,0.002391604,0.002578071,0.001312282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.06074042,0.00276965,0.1919059,0.004465672,0.002684249,0.001116278,0.1028237,0.01657045,0.03996873,0.001205421,0.003301046,0.5724484],"study_design_scores_gemma":[0.01904432,0.00452847,0.9377536,0.001938673,0.001292947,0.004204595,0.02062583,0.001227037,0.002923956,0.0000789219,0.005409287,0.0009723184],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9543533,0.009298145,0.003675441,0.02720656,0.0004606939,0.003346735,0.0001594664,0.0001259175,0.001373794],"genre_scores_gemma":[0.990159,0.002034477,0.002306428,0.0006150327,0.004370414,0.00002451275,0.00007146656,0.0001652809,0.0002534165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7458478,"threshold_uncertainty_score":0.9999658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02725816962532538,"score_gpt":0.3109434997256892,"score_spread":0.2836853301003638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}