{"id":"W2782817020","doi":"10.4049/jimmunol.1701021","title":"Critical Interactions between Immunogenic Cancer Cell Death, Oncolytic Viruses, and the Immune System Define the Rational Design of Combination Immunotherapies","year":2018,"lang":"en","type":"review","venue":"The Journal of Immunology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre; University of Guelph","funders":"","keywords":"Oncolytic virus; Immunogenic cell death; Immune system; Rational design; Virology; Immunotherapy; Cancer immunotherapy; Cancer; Biology; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003704201,0.0003379162,0.001076622,0.0001095605,0.0004119688,0.00004874916,0.001239429,0.00027253,0.0000572067],"category_scores_gemma":[0.000279152,0.0001606735,0.0004629783,0.0001712148,0.001426392,0.0000173969,0.0002607523,0.0007395843,0.000008856169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001827721,"about_ca_system_score_gemma":0.0008899595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001483613,"about_ca_topic_score_gemma":0.00003577029,"domain_scores_codex":[0.9942085,0.003750914,0.001261359,0.0001892476,0.0002933576,0.0002966964],"domain_scores_gemma":[0.9952326,0.002045056,0.001257961,0.0007605956,0.0006732667,0.00003045302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.04669974,0.001187111,0.00004426195,0.006827969,0.04117845,0.00001791942,0.003115313,0.0001620428,0.354417,0.007179173,0.001755466,0.5374156],"study_design_scores_gemma":[0.01889852,0.02731362,0.0003892001,0.01388967,0.0168482,0.006202173,0.00322029,0.0001702351,0.1572756,0.001677051,0.7520808,0.002034637],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003997446,0.9930393,0.001351378,0.0003432182,0.0004452976,0.0007344229,0.00004253249,0.000004123842,0.00004233875],"genre_scores_gemma":[0.04185915,0.9573915,0.0000834477,0.00004185437,0.0003737313,0.00007629702,0.0000181496,0.00005288376,0.0001029551],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7503253,"threshold_uncertainty_score":0.6552077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06077755792915855,"score_gpt":0.3710058980934239,"score_spread":0.3102283401642654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}