{"id":"W2782830751","doi":"10.1021/acs.jproteome.7b00817","title":"Proteomic Profiling of <i>Leishmania donovani</i> Promastigote Subcellular Organelles","year":2018,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Genome British Columbia; University of Victoria; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Warren Y. Soper Charitable Trust; Fondation De Famille Alvin Segal; Jewish General Hospital; Leading Edge Endowment Fund; Genome British Columbia; Institute of Infection and Immunity; Segal Family Foundation; Genome Canada; Wellcome Trust; McGill University","keywords":"Proteome; Organelle; Cell fractionation; Subcellular localization; Leishmania donovani; Leishmania; Biology; Proteomics; Cell biology; Immunoelectron microscopy; Leishmania mexicana; Biochemistry; Computational biology; Leishmaniasis; Parasite hosting; Membrane; Cytoplasm; Visceral leishmaniasis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008542587,0.0002675166,0.0009697481,0.001337451,0.0003265343,0.00007701597,0.0007085998,0.0001884611,0.0002469753],"category_scores_gemma":[0.004122964,0.0001949669,0.0002712316,0.001654397,0.001417099,0.0003394406,0.0004474591,0.001806499,0.0001460183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003489377,"about_ca_system_score_gemma":0.001721886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004538727,"about_ca_topic_score_gemma":0.000004832552,"domain_scores_codex":[0.9933335,0.0005844502,0.001320152,0.0003982754,0.003341505,0.001022087],"domain_scores_gemma":[0.9903139,0.0002380526,0.0006005336,0.000635594,0.007747497,0.0004643644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002175491,0.0005292012,0.02360194,0.001073481,0.0004029057,0.0004129666,0.0005606171,0.000001015166,0.966876,0.0002500155,0.002509922,0.001606408],"study_design_scores_gemma":[0.002587841,0.00784362,0.01110037,0.001087775,0.00006309141,0.0005615695,0.0004772695,0.0001140676,0.9715721,0.001012544,0.003400907,0.0001788711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989001,0.001359375,0.0004841569,0.003256095,0.0001372402,0.003243226,0.00000594324,0.00002541433,0.002487558],"genre_scores_gemma":[0.9683233,0.0005368723,0.02829363,0.00002728261,0.001547769,0.00008376037,0.000001945914,0.00008392483,0.001101499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02780947,"threshold_uncertainty_score":0.7950518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09064934389339493,"score_gpt":0.3940551105221761,"score_spread":0.3034057666287812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}