{"id":"W2782871520","doi":"10.1016/j.ejps.2018.01.014","title":"Solid dispersions to enhance the delivery of a potential drug candidate LPSF/FZ4 for the treatment of schistosomiasis","year":2018,"lang":"en","type":"article","venue":"European Journal of Pharmaceutical Sciences","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco; Government of Canada","keywords":"Bioavailability; Dissolution; Solubility; Cmax; In vivo; Materials science; Chemistry; Chromatography; Drug delivery; Nuclear chemistry; Pharmacology; Biotechnology; Biology; Nanotechnology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009927213,0.0001938801,0.0001522206,0.0002439296,0.0001309795,0.0001792835,0.0001144261,0.0002443653,0.001320143],"category_scores_gemma":[0.000139392,0.00009298743,0.0001557377,0.0001056917,0.0001089495,0.0001598959,0.0001955175,0.0003526766,0.0002592942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001992851,"about_ca_system_score_gemma":0.0002073324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009865749,"about_ca_topic_score_gemma":0.001809357,"domain_scores_codex":[0.9999387,0.00001156707,0.000004619909,0.000009632583,0.00002194126,0.00001353772],"domain_scores_gemma":[0.9999626,0.000009070299,0.00001013608,0.000001878683,0.000008654345,0.000007607845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001321246,0.0000438229,0.00005429338,0.00008530558,0.000007838423,0.0000401324,0.00001528726,0.0003851413,0.9933738,0.0001585408,0.0001132278,0.005590485],"study_design_scores_gemma":[0.00003086807,0.0004715412,0.0006418995,0.00001084421,0.00002903883,0.00008230378,0.00001764993,0.002180948,0.9926853,0.00004502007,0.003797535,0.000007047598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904222,0.002463201,0.004778478,0.0001517906,0.00005774062,0.0000436158,0.0001379081,0.00007748952,0.001867601],"genre_scores_gemma":[0.9905038,0.001315069,0.004503359,0.00003365616,0.00001505433,0.00002702247,0.0001171682,0.00001625118,0.003468583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001320143,"threshold_uncertainty_score":0.004416347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1056095018196593,"score_gpt":0.4635692987244674,"score_spread":0.3579597969048081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}