{"id":"W2782876837","doi":"10.1200/po.17.00098","title":"Reflex Testing for Germline<i>BRCA1</i>,<i>BRCA2</i>,<i>PALB2</i>, and<i>ATM</i>Mutations in Pancreatic Cancer: Mutation Prevalence and Clinical Outcomes From Two Canadian Research Registries","year":2018,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"PALB2; Germline mutation; Medicine; Founder effect; Breast cancer; Internal medicine; Pancreatic cancer; Oncology; Cancer; Mutation; Genetics; Gene; Biology; Genotype; Haplotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001421893,0.0003190125,0.0002663209,0.001297762,0.0008087608,0.0006269323,0.001021319,0.0002675167,0.0008437511],"category_scores_gemma":[0.006083586,0.0002238987,0.0002956951,0.001868445,0.0007068285,0.0002198896,0.0006987739,0.0003068852,0.0001203952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004707745,"about_ca_system_score_gemma":0.005560101,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.7734923,"about_ca_topic_score_gemma":0.807755,"domain_scores_codex":[0.9985926,0.0001836332,0.0001171604,0.0002841154,0.0005443554,0.0002781462],"domain_scores_gemma":[0.9958786,0.0006564212,0.001325304,0.0003768473,0.001259001,0.0005038448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003215901,0.000006361072,0.9975277,0.000008797085,0.00001458116,0.00005161756,0.00008981794,0.00005995462,0.0002119368,0.00001139381,0.00008998752,0.001895803],"study_design_scores_gemma":[0.000008375255,0.00004164957,0.9983909,0.00001298405,0.00003322852,0.0003910793,0.0002775506,0.0002394608,0.0002734864,0.00001143264,0.0003144674,0.000005486443],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982664,0.0002834849,0.00007688313,0.00005382285,0.000002034566,0.00001530149,0.0006432117,0.00001175453,0.0006470801],"genre_scores_gemma":[0.998944,0.0001714956,0.0001747825,0.00003194217,0.000002306339,0.000004498886,0.0005936635,0.000002143139,0.00007523852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2265077,"threshold_uncertainty_score":0.4556832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1042849135584613,"score_gpt":0.4542859682781856,"score_spread":0.3500010547197242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}