{"id":"W2782876837","doi":"10.1200/po.17.00098","title":"Reflex Testing for Germline<i>BRCA1</i>,<i>BRCA2</i>,<i>PALB2</i>, and<i>ATM</i>Mutations in Pancreatic Cancer: Mutation Prevalence and Clinical Outcomes From Two Canadian Research Registries","year":2018,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"PALB2; Germline mutation; Medicine; Founder effect; Breast cancer; Internal medicine; Pancreatic cancer; Oncology; Cancer; Mutation; Genetics; Gene; Biology; Genotype; Haplotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001464992,0.0001961823,0.0003815281,0.0001723224,0.0003126431,0.00007174085,0.0002288638,0.0003230834,0.00002285749],"category_scores_gemma":[0.005921374,0.0001931301,0.00006079205,0.0002255786,0.0005982508,0.00001494582,0.0001933526,0.0002457738,0.000005886113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001983823,"about_ca_system_score_gemma":0.001264526,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.04086352,"about_ca_topic_score_gemma":0.3708471,"domain_scores_codex":[0.9976344,0.0002962759,0.0006486548,0.0007701851,0.0001616161,0.0004888761],"domain_scores_gemma":[0.9954415,0.003139371,0.0001902232,0.0003979423,0.0005398778,0.0002911047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006596579,0.000120307,0.8271946,0.00005010378,0.000108887,0.00002562767,0.0004369333,0.00004758707,0.007026375,0.0002691545,0.006604338,0.1574565],"study_design_scores_gemma":[0.00603866,0.004547738,0.8035908,0.0002153003,0.0001912199,0.00003231339,0.0003188033,0.001420225,0.003843411,0.007776854,0.1714182,0.000606477],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927468,0.002827033,0.0002877805,0.00160663,0.0004812256,0.0008580366,0.0004403387,0.00001199544,0.0007401495],"genre_scores_gemma":[0.9838072,0.00270885,0.01081891,0.001070994,0.0008636139,0.0002497981,0.0001634578,0.00003618584,0.0002809955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3299836,"threshold_uncertainty_score":0.9655235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1042849135584613,"score_gpt":0.4542859682781856,"score_spread":0.3500010547197242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}