{"id":"W2783085151","doi":"10.1016/j.cbpb.2018.01.003","title":"Increased transcript levels and kinetic function of pyruvate kinase during severe dehydration in aestivating African clawed frogs, Xenopus laevis","year":2018,"lang":"en","type":"article","venue":"Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology","topic":"Physiological and biochemical adaptations","field":"Environmental Science","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada; Karen Brown Scleroderma Foundation","keywords":"Xenopus; Glycolysis; Biology; Pyruvate kinase; Dehydration; African clawed frog; Internal medicine; Phosphorylation; Endocrinology; Phosphoenolpyruvate carboxykinase; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009343301,0.0002143171,0.0002439819,0.0003640795,0.0003018665,0.0003505126,0.0001557609,0.0002490285,0.001459217],"category_scores_gemma":[0.0001588553,0.0002596296,0.0002155018,0.0001726114,0.0003709684,0.0003622767,0.0002020015,0.0004228967,0.0002212946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002976391,"about_ca_system_score_gemma":0.0001540909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001593855,"about_ca_topic_score_gemma":0.002452202,"domain_scores_codex":[0.9999186,0.000007822979,0.000005142269,0.00003484097,0.00001013164,0.00002348536],"domain_scores_gemma":[0.9998472,0.00002212767,0.0000551991,0.00001376091,0.00002403758,0.00003760154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003539147,0.00001118778,0.00261471,0.00002488814,0.000006727394,0.00004239462,0.00008432567,0.00004376886,0.9961964,0.00009543448,0.00002084328,0.0005054489],"study_design_scores_gemma":[0.00005367835,0.0007321769,0.6275762,0.00001883765,0.0000751106,0.0007930465,0.0006430517,0.001029997,0.3669915,0.000228638,0.001825477,0.00003223566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984381,0.0003240345,0.0003688399,0.00003674894,0.000005792035,0.000004678823,0.0004429588,0.00001471842,0.0003641309],"genre_scores_gemma":[0.9951344,0.0002060861,0.000524945,0.00004642568,0.00001011777,0.00003025547,0.0009153523,0.00001446801,0.003117982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001593855,"threshold_uncertainty_score":0.004881561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02017076636690518,"score_gpt":0.2478644711736262,"score_spread":0.227693704806721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}