{"id":"W2783099657","doi":"10.1038/s41467-017-02252-2","title":"Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; National Institutes of Health; Cold Spring Harbor Laboratory; National Institute of General Medical Sciences; University of Windsor; Don Monti Memorial Research Foundation; Howard Hughes Medical Institute","keywords":"Protein tyrosine phosphatase; Small molecule; Regulator; Leptin; Glucose homeostasis; Insulin; Diabetes mellitus; Chemistry; Function (biology); Signal transduction; Biochemistry; Cell biology; Biology; Obesity; Insulin resistance; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002662793,0.0003436044,0.0002161424,0.0001607325,0.00009665374,0.0003701847,0.0002019353,0.0003100203,0.0009092608],"category_scores_gemma":[0.0001565877,0.0001461467,0.0002142515,0.0001106205,0.0002129883,0.0002690804,0.0002582552,0.0005993642,0.0001899971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002445828,"about_ca_system_score_gemma":0.0002299873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002302763,"about_ca_topic_score_gemma":0.0003308286,"domain_scores_codex":[0.9998981,0.00001721303,0.000005988858,0.00001972336,0.00003125313,0.00002780013],"domain_scores_gemma":[0.9999446,0.00000734847,0.00002455145,0.000005737498,0.000005858085,0.0000119338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008174353,0.00004690869,0.0001369371,0.00008392689,0.00001307319,0.0001043595,0.00001678661,0.0003919504,0.9884708,0.001492999,0.0001373584,0.00902316],"study_design_scores_gemma":[0.00008068793,0.0007671173,0.0009328999,0.00001829681,0.00004508652,0.0005324166,0.00001652576,0.002501931,0.9811834,0.0005836049,0.0133292,0.000008781687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8962911,0.02041306,0.06983417,0.001419138,0.0002524441,0.0002353682,0.000301052,0.0003166305,0.01093695],"genre_scores_gemma":[0.9827608,0.006318906,0.00910175,0.0001654597,0.00003224376,0.00005545734,0.0001337479,0.00001769436,0.001413962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009092608,"threshold_uncertainty_score":0.003041804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0322231059923583,"score_gpt":0.3257200382566578,"score_spread":0.2934969322642995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}