{"id":"W2783116181","doi":"10.1016/j.celrep.2017.12.060","title":"Esrrb Complementation Rescues Development of Nanog-Null Germ Cells","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Directorate for Biological Sciences; National Institute for Health and Care Research; Medical Research Council Canada; NIHR Imperial Biomedical Research Centre; University of Cambridge; Cancer Research UK; Wellcome Trust","keywords":"Homeobox protein NANOG; Biology; Germline; Embryonic stem cell; Rex1; Nanog Homeobox Protein; Complementation; Cell biology; Null cell; Germ cell; Genetics; Induced pluripotent stem cell; Phenotype; Cell culture; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003867093,0.0001185624,0.0001293728,0.00005518164,0.00009669408,0.00001359759,0.0001229741,0.0000813208,0.0001529155],"category_scores_gemma":[0.00002161733,0.0001148534,0.00005326335,0.00008058418,0.0001088312,0.00000325755,0.0001736362,0.00004460476,0.00003960322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002312559,"about_ca_system_score_gemma":0.0002051359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001560022,"about_ca_topic_score_gemma":0.00003832213,"domain_scores_codex":[0.9985873,0.000042223,0.0004593029,0.0003592454,0.0002950408,0.0002569405],"domain_scores_gemma":[0.9990351,0.000006875364,0.0002300017,0.0004215147,0.0002235592,0.00008300749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002580764,0.00007156724,0.001605636,0.00005060373,0.00002022666,0.00002590607,0.0001512447,0.000003427713,0.9911761,0.0000018732,0.005418689,0.001448893],"study_design_scores_gemma":[0.0001486652,0.0001183505,0.001545305,0.00001174889,0.000005618554,0.00001714222,0.0000549209,0.000007930165,0.8754174,0.00001434511,0.1225467,0.0001118314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851007,0.0001749168,0.001131268,0.00001408728,0.0002462271,0.0002361718,0.00000357433,0.000009639774,0.01308342],"genre_scores_gemma":[0.9898059,0.00003794216,0.005476463,0.00003504819,0.0001237399,0.0000139171,0.0001528761,0.00001925117,0.004334914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1171281,"threshold_uncertainty_score":0.4683584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01994691165154361,"score_gpt":0.29193372231121,"score_spread":0.2719868106596664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}