{"id":"W2783116181","doi":"10.1016/j.celrep.2017.12.060","title":"Esrrb Complementation Rescues Development of Nanog-Null Germ Cells","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Directorate for Biological Sciences; National Institute for Health and Care Research; Medical Research Council Canada; NIHR Imperial Biomedical Research Centre; University of Cambridge; Cancer Research UK; Wellcome Trust","keywords":"Homeobox protein NANOG; Biology; Germline; Embryonic stem cell; Rex1; Nanog Homeobox Protein; Complementation; Cell biology; Null cell; Germ cell; Genetics; Induced pluripotent stem cell; Phenotype; Cell culture; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000181165,0.0004164494,0.0003492689,0.000386251,0.000124394,0.0002588923,0.0003664917,0.0004316825,0.002476027],"category_scores_gemma":[0.00009944456,0.0002223642,0.0003077636,0.0001172235,0.0003888082,0.0001304588,0.000345617,0.0007416455,0.0009969914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001517186,"about_ca_system_score_gemma":0.0002051784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004404198,"about_ca_topic_score_gemma":0.0007768351,"domain_scores_codex":[0.9997748,0.0000269475,0.00002887231,0.00005081815,0.00008345315,0.00003526899],"domain_scores_gemma":[0.9997181,0.00004456609,0.00009678922,0.00003971737,0.00001493632,0.00008586457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002527515,0.0000111673,0.00007794514,0.00001774006,0.000003115229,0.00007487301,0.00000839232,0.00004419488,0.999078,0.00008110215,0.00002076196,0.0005574623],"study_design_scores_gemma":[0.00001707019,0.00008352724,0.002212492,0.000007395557,0.00001123441,0.0003298153,0.00002219254,0.0005529981,0.9937325,0.00003374217,0.002992505,0.000004591235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864548,0.00095234,0.008077619,0.0001673188,0.00006879618,0.00002661539,0.001031141,0.0008097058,0.002411603],"genre_scores_gemma":[0.980633,0.0007692433,0.003842748,0.00008423501,0.00001596552,0.00003947458,0.001169392,0.0003565077,0.01308946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002476027,"threshold_uncertainty_score":0.008283138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01994691165154361,"score_gpt":0.29193372231121,"score_spread":0.2719868106596664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}