{"id":"W2783125404","doi":"10.1021/acsami.7b18809","title":"Nanostructured Peptidotoxins as Natural Pro-Oxidants Induced Cancer Cell Death via Amplification of Oxidative Stress","year":2018,"lang":"en","type":"article","venue":"ACS Applied Materials & Interfaces","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Priority Academic Program Development of Jiangsu Higher Education Institutions; China Association for Science and Technology; Government of Jiangsu Province; Natural Science Foundation of Jiangsu Province; Nanjing University of Chinese Medicine; National Natural Science Foundation of China; National Science Foundation","keywords":"Reactive oxygen species; Cancer cell; Oxidative stress; Lysosome; Nanocarriers; Programmed cell death; Biochemistry; Endocytosis; Biophysics; Cancer; Cell biology; Chemistry; Apoptosis; Materials science; Drug delivery; Biology; Cell; Nanotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006756492,0.0001834915,0.0001138932,0.00009407644,0.0000672579,0.0001717472,0.0001279999,0.0002630098,0.0003885729],"category_scores_gemma":[0.00009031448,0.00009521905,0.0001460375,0.00006589448,0.0001151912,0.000224368,0.0001497086,0.0002553684,0.0001346667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001881693,"about_ca_system_score_gemma":0.00008046372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001335948,"about_ca_topic_score_gemma":0.0003221228,"domain_scores_codex":[0.9999453,0.000006367404,0.000004430436,0.00001483693,0.00001747919,0.00001156397],"domain_scores_gemma":[0.9999589,0.000005596166,0.00001483816,0.000003556573,0.000008796669,0.000008422709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001841867,0.000004992064,0.00003766018,0.00003054198,0.00000190338,0.00002050736,0.000006722319,0.00005087843,0.9987759,0.00006631375,0.00001452733,0.0009715607],"study_design_scores_gemma":[0.000006441063,0.0001377457,0.0004038822,0.000002932346,0.000006587046,0.00006946432,0.000008680079,0.0006383563,0.9972298,0.00002525494,0.001468275,0.000002759548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863904,0.00296035,0.008377594,0.00009418405,0.00005963505,0.00003811518,0.00009761599,0.0001076801,0.0018745],"genre_scores_gemma":[0.9932724,0.0009651638,0.004025827,0.00007090857,0.000008873283,0.00003225913,0.00008218904,0.00001052244,0.001531792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003885729,"threshold_uncertainty_score":0.001365304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01315444693664138,"score_gpt":0.249382794036296,"score_spread":0.2362283470996547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}