{"id":"W2783128531","doi":"10.1016/j.cardfail.2017.12.009","title":"Insertional Mutagenesis Confounds the Mechanism of the Morbid Phenotype of a PLN R9C Transgenic Mouse Line","year":2018,"lang":"en","type":"article","venue":"Journal of Cardiac Failure","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs","funders":"","keywords":"Insertional mutagenesis; Transgene; Phenotype; Genetically modified mouse; Mutagenesis; Medicine; Line (geometry); Mechanism (biology); Genetics; Mouse strain; Gene knockin; Mutation; Molecular biology; Gene; Mutant; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000381373,0.00009757563,0.0001940106,0.00002837679,0.00006884109,0.000007410326,0.0002384324,0.0001098861,0.00002087827],"category_scores_gemma":[0.00005340706,0.00005397381,0.0003819746,0.0001043526,0.0001916231,0.000003753433,0.00004795145,0.0001076425,0.000001024909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007509812,"about_ca_system_score_gemma":0.0001527766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008456641,"about_ca_topic_score_gemma":0.00001093305,"domain_scores_codex":[0.9990893,0.00008858683,0.0003395944,0.0001160108,0.0002650035,0.0001015168],"domain_scores_gemma":[0.9987532,0.000008720545,0.0003432596,0.000291408,0.0005688353,0.0000345253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001572906,0.00003570285,0.0001929753,0.00001356191,0.0002447939,1.169936e-7,0.0001330463,0.0001255137,0.9973843,0.0003365961,0.0009171863,0.0004589187],"study_design_scores_gemma":[0.0002367986,0.000620199,0.002838217,0.00001390273,0.0001366453,0.00001677916,0.0001639881,0.00001339892,0.967922,0.000176449,0.02779474,0.0000668331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963366,0.001008633,0.001045572,0.0008380508,0.000483741,0.0001027053,0.00002245828,0.000001199988,0.000161062],"genre_scores_gemma":[0.9975982,0.000357499,0.0004290601,0.00006968561,0.001098334,0.000001456688,0.000003022199,0.00001342379,0.0004292792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02946225,"threshold_uncertainty_score":0.2200988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009041902139547872,"score_gpt":0.2314145503640381,"score_spread":0.2223726482244903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}