{"id":"W2783139321","doi":"10.2147/ott.s155511","title":"Progranulin modulates cholangiocarcinoma cell proliferation, apoptosis, and motility via the PI3K/pAkt pathway","year":2018,"lang":"en","type":"article","venue":"OncoTargets and Therapy","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Associated Medical Services","funders":"Thailand Research Fund; Khon Kaen University","keywords":"Cell growth; Motility; PI3K/AKT/mTOR pathway; Annexin; Cyclin D1; Vimentin; Apoptosis; Protein kinase B; Cancer research; Gene knockdown; Cell cycle; Biology; Cell biology; Signal transduction; Chemistry; Immunology; Immunohistochemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003979341,0.0001835839,0.0002384153,0.00004264627,0.0003348609,0.00009161948,0.0000939813,0.00009919198,0.0001833288],"category_scores_gemma":[0.00001597891,0.00009923313,0.00005314144,0.0001384518,0.0003577022,0.0001082359,0.00005202062,0.0002049286,0.00001947197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002403442,"about_ca_system_score_gemma":0.00004835606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001511501,"about_ca_topic_score_gemma":0.00001043983,"domain_scores_codex":[0.9987192,0.0001010552,0.0002096961,0.0003559016,0.0002829146,0.0003312052],"domain_scores_gemma":[0.9992266,0.00003770534,0.00005186709,0.0003213509,0.0001817092,0.0001807902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001047546,0.000750727,0.5009975,0.0001087527,0.0001709665,0.000006415186,0.004475273,6.03112e-7,0.2292195,0.0001686446,0.001258362,0.2617957],"study_design_scores_gemma":[0.002925891,0.001992225,0.9090826,0.00003405072,0.00001846466,0.00002356383,0.00005162853,0.002118784,0.06292104,0.001151432,0.01949133,0.0001889758],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907544,0.003933367,0.00009756118,0.003562441,0.00006616312,0.0009361581,0.00000611808,0.00004888871,0.0005949175],"genre_scores_gemma":[0.9962181,0.001468698,0.0004514794,0.0007780928,0.0004465058,0.00006482413,0.00001665509,0.00002552661,0.0005300519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4080851,"threshold_uncertainty_score":0.4046609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02006550453381741,"score_gpt":0.2687902656443901,"score_spread":0.2487247611105727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}