{"id":"W2783214188","doi":"10.1021/acschembio.7b01085","title":"Genetically Encoded Glutamate Indicators with Altered Color and Topology","year":2018,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Government of Canada; University Hospital Foundation; Institute of Neurosciences, Mental Health and Addiction; University of Alberta; Alberta Innovates - Health Solutions; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada","keywords":"Glutamate receptor; Hippocampal formation; Neuroscience; Fluorescence; HEK 293 cells; Amino acid; Biology; Metabotropic glutamate receptor 6; Chemistry; Biophysics; Cell biology; Biochemistry; Metabotropic glutamate receptor; Gene; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008243233,0.0001406465,0.0002022025,0.00008841679,0.00008892838,0.00001919842,0.000348201,0.0002051048,0.0002501583],"category_scores_gemma":[0.0003734937,0.0001016293,0.00001895542,0.0002373648,0.002455752,0.00002149827,0.0002665336,0.0001835908,0.00009323118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001999184,"about_ca_system_score_gemma":0.00005242717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009426029,"about_ca_topic_score_gemma":0.00000541986,"domain_scores_codex":[0.998587,0.0001121451,0.0001673969,0.0005270658,0.0001084426,0.0004979806],"domain_scores_gemma":[0.9992121,0.0002854679,0.00004475274,0.0002283909,0.00003872572,0.0001905105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001983645,0.00003564076,0.003304746,0.000003850775,0.000006172171,0.00000380913,0.0000700239,2.579748e-8,0.9922701,0.00175777,0.0001371693,0.002212306],"study_design_scores_gemma":[0.0004953168,0.0006897627,0.0003391564,0.000002435442,0.000005318629,0.00005639099,0.000006912192,0.00005958913,0.9917983,0.001034132,0.005377742,0.0001348819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958882,0.00002977743,0.00007222124,0.0004181213,0.0001073304,0.0001682922,0.00002055253,0.00004188035,0.003253673],"genre_scores_gemma":[0.9978678,0.00009235715,0.000746745,0.001023611,0.0001619706,0.0000275384,0.000006013465,0.00001386711,0.00006006936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005240573,"threshold_uncertainty_score":0.9048321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0244826750790504,"score_gpt":0.3117641892258657,"score_spread":0.2872815141468154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}