{"id":"W2783214188","doi":"10.1021/acschembio.7b01085","title":"Genetically Encoded Glutamate Indicators with Altered Color and Topology","year":2018,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Government of Canada; University Hospital Foundation; Institute of Neurosciences, Mental Health and Addiction; University of Alberta; Alberta Innovates - Health Solutions; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada","keywords":"Glutamate receptor; Hippocampal formation; Neuroscience; Fluorescence; HEK 293 cells; Amino acid; Biology; Metabotropic glutamate receptor 6; Chemistry; Biophysics; Cell biology; Biochemistry; Metabotropic glutamate receptor; Gene; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002145147,0.0004690778,0.0002245407,0.000179763,0.0001154829,0.0003861506,0.0004704023,0.0004015819,0.0005378528],"category_scores_gemma":[0.0003252222,0.0001634837,0.0002406931,0.0001897183,0.0003697302,0.000316971,0.0004064828,0.0006196266,0.0003042282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000572674,"about_ca_system_score_gemma":0.0001950611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004328307,"about_ca_topic_score_gemma":0.0006096538,"domain_scores_codex":[0.999809,0.00003244455,0.00001792654,0.00004017892,0.00006232798,0.00003827704],"domain_scores_gemma":[0.9997514,0.00003347425,0.0001152281,0.00002952678,0.00002924068,0.00004110545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001669209,0.000004396821,0.00003688329,0.00001142859,0.000001711816,0.00002795444,0.000007198278,0.00009019062,0.9990243,0.0002176914,0.00001339557,0.0005481857],"study_design_scores_gemma":[0.000004301005,0.00004125516,0.0002819173,0.000001758892,0.000005393579,0.0001241372,0.000005530633,0.0006214997,0.997793,0.00002703686,0.001089858,0.000004459506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735438,0.0003393434,0.02311831,0.0001821315,0.00003842485,0.00005318872,0.0003141376,0.0003343773,0.002076315],"genre_scores_gemma":[0.9679641,0.0005494893,0.02819607,0.00009478242,0.00001044331,0.00006489361,0.000510786,0.0001252015,0.002484198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000572674,"threshold_uncertainty_score":0.004155099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0244826750790504,"score_gpt":0.3117641892258657,"score_spread":0.2872815141468154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}