{"id":"W2783256086","doi":"10.1016/j.ejps.2018.01.021","title":"Metabolism and pharmacokinetics of a potent N-acylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) in rats and monkeys","year":2018,"lang":"en","type":"article","venue":"European Journal of Pharmaceutical Sciences","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Concordia University; McGill University Health Centre","funders":"Division of Chemistry; National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; American Asthma Foundation; National Science Foundation; National Institutes of Health; Concordia University; Canadian Institutes of Health Research; McGill University Health Centre","keywords":"Chemotaxis; Eosinophil; Pharmacology; Antagonist; In vivo; Microsome; Pharmacokinetics; In vitro; Chemistry; Metabolite; Receptor; Potency; Receptor antagonist; Biochemistry; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001641051,0.0001600285,0.0003472377,0.0000964936,0.0002157085,0.00003799806,0.0003666964,0.00002347162,0.00004076053],"category_scores_gemma":[0.0003074568,0.00007652206,0.0001345818,0.0003423232,0.00228615,0.000118182,0.0001235903,0.0002396691,0.00000106471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001345228,"about_ca_system_score_gemma":0.0001546129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002401305,"about_ca_topic_score_gemma":0.000001204049,"domain_scores_codex":[0.9980821,0.0003056263,0.0006405527,0.0001946346,0.0005070934,0.0002700169],"domain_scores_gemma":[0.9987798,0.0002017693,0.0003994245,0.0001257742,0.0002401302,0.0002531531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009260503,0.0004290374,0.01132269,0.0001504073,0.00007761767,0.00003488116,0.0006621112,0.00001583227,0.8931767,0.0001020385,0.0004801895,0.09262245],"study_design_scores_gemma":[0.004429635,0.001190432,0.1417198,0.0003247885,0.0004671612,0.0001881517,0.0006206661,0.001341535,0.7891071,0.00004277477,0.06039833,0.0001696354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876087,0.00719858,0.00009345873,0.003917739,0.0004590008,0.00032785,0.00001880764,0.000004160906,0.0003716813],"genre_scores_gemma":[0.9971575,0.001190899,0.0005021162,0.0006844302,0.0004237513,0.000001111057,2.337539e-7,0.00001366384,0.00002625906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1303971,"threshold_uncertainty_score":0.8423416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04536908432455247,"score_gpt":0.3376479773906765,"score_spread":0.2922788930661241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}