{"id":"W2783256086","doi":"10.1016/j.ejps.2018.01.021","title":"Metabolism and pharmacokinetics of a potent N-acylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) in rats and monkeys","year":2018,"lang":"en","type":"article","venue":"European Journal of Pharmaceutical Sciences","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Concordia University; McGill University Health Centre","funders":"Division of Chemistry; National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; American Asthma Foundation; National Science Foundation; National Institutes of Health; Concordia University; Canadian Institutes of Health Research; McGill University Health Centre","keywords":"Chemotaxis; Eosinophil; Pharmacology; Antagonist; In vivo; Microsome; Pharmacokinetics; In vitro; Chemistry; Metabolite; Receptor; Potency; Receptor antagonist; Biochemistry; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002683848,0.0004368521,0.0004661533,0.0004010792,0.000247292,0.0006125981,0.0002762451,0.0005818895,0.001214051],"category_scores_gemma":[0.0005387482,0.0005214767,0.0003435978,0.000193764,0.0004688649,0.0006161002,0.0001090093,0.0006846866,0.0008266959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006042038,"about_ca_system_score_gemma":0.0004545414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002829236,"about_ca_topic_score_gemma":0.002069553,"domain_scores_codex":[0.9998444,0.00005130957,0.000006456708,0.00003371468,0.00001608957,0.00004795777],"domain_scores_gemma":[0.9997272,0.00006915257,0.00006092819,0.00004205298,0.00001821696,0.0000825071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.07922564,0.002650804,0.00708106,0.0001411133,0.0002742136,0.0007300216,0.0005384274,0.002294878,0.856884,0.001251442,0.001350888,0.0475775],"study_design_scores_gemma":[0.004250849,0.0953374,0.08950962,0.0000504698,0.001083224,0.002748972,0.000865137,0.02309749,0.7674919,0.001535649,0.01384445,0.0001847858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961588,0.001486297,0.0008404595,0.00008077731,0.0000256761,0.00003529828,0.0002755055,0.00005437187,0.001043],"genre_scores_gemma":[0.9947751,0.001356985,0.0005060691,0.00006263229,0.00004610893,0.00005655638,0.0004826594,0.00005108419,0.002662784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002829236,"threshold_uncertainty_score":0.005625546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04536908432455247,"score_gpt":0.3376479773906765,"score_spread":0.2922788930661241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}