{"id":"W2783256919","doi":"10.1002/1878-0261.12167","title":"Dual inhibition of Wnt and Yes‐associated protein signaling retards the growth of triple‐negative breast cancer in both mesenchymal and epithelial states","year":2018,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Ontario Institute for Cancer Research; Health Canada; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canadian Cancer Society","keywords":"Wnt signaling pathway; Breast cancer; Triple-negative breast cancer; Cancer research; Mesenchymal stem cell; Dual (grammatical number); Chemistry; Dual role; Signal transduction; Biology; Cell biology; Medicine; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004637759,0.0001365972,0.000246731,0.00005819134,0.00005037742,0.000007011317,0.00007054409,0.0001800251,0.00002718702],"category_scores_gemma":[0.00009331029,0.000108325,0.00003830523,0.0001452165,0.0005164309,0.000005416844,0.0001041231,0.0001016389,2.452888e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004101462,"about_ca_system_score_gemma":0.0002230151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000376664,"about_ca_topic_score_gemma":0.0003616712,"domain_scores_codex":[0.9988738,0.0002244795,0.0003051148,0.0002613369,0.0001346423,0.0002006315],"domain_scores_gemma":[0.9994153,0.00002417404,0.0002153384,0.00008714071,0.000221105,0.00003694845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003860354,0.0000544207,0.002969699,0.00002418104,0.0001020904,0.000007801155,0.0007171665,0.00001318354,0.9945844,0.00008673323,0.0000707026,0.0009835331],"study_design_scores_gemma":[0.00148181,0.0006997401,0.0147272,0.00007627709,0.00003432946,0.00001170762,0.0002040772,0.00008187089,0.9815296,0.0009409596,0.000073812,0.0001386259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982594,0.0004817931,0.0001823541,0.0004955246,0.00006703047,0.0003163593,0.00009119904,0.000004020481,0.0001022763],"genre_scores_gemma":[0.9992742,0.0001433013,0.0002344927,0.0001264491,0.00006900805,0.0000586665,0.00002773784,0.00001481248,0.00005130935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01305486,"threshold_uncertainty_score":0.4417365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006714959615217786,"score_gpt":0.252287588982591,"score_spread":0.2455726293673732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}