{"id":"W2783265629","doi":"10.3390/v10010036","title":"Interferons: Reprogramming the Metabolic Network against Viral Infection","year":2018,"lang":"en","type":"review","venue":"Viruses","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Biology; SAMHD1; Interferon; Viral replication; Immune system; Innate immune system; Reprogramming; Intrinsic immunity; Cell biology; Transcription factor; Virology; Virus; Immunology; Genetics; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002270401,0.0005423444,0.0005484853,0.001226463,0.000257283,0.0007479549,0.0004588419,0.0006980501,0.002363975],"category_scores_gemma":[0.0002844076,0.0001310407,0.00027922,0.0007750487,0.0002898924,0.0008324471,0.0004936589,0.001006545,0.001170672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00045484,"about_ca_system_score_gemma":0.0007181944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005306461,"about_ca_topic_score_gemma":0.0009298902,"domain_scores_codex":[0.9999126,0.00001521443,0.00001381323,0.00001698035,0.00002960887,0.00001173989],"domain_scores_gemma":[0.9999268,0.0000234497,0.00001458031,0.000002909124,0.00002140918,0.00001085662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000648132,0.000055003,0.0002690755,0.01169275,0.00007294973,0.0002626124,0.0001132808,0.0003537225,0.006077556,0.007343724,0.02663923,0.9470553],"study_design_scores_gemma":[0.000007226809,0.0000501234,0.0007128283,0.001612667,0.00004315858,0.001185727,0.00006025492,0.00007577102,0.0009291334,0.002333343,0.9929793,0.00001036313],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003779618,0.9960809,0.0003399221,0.0004459065,0.0003100713,0.000007334108,0.00003014182,0.000019696,0.002388063],"genre_scores_gemma":[0.001861924,0.9962953,0.0002875629,0.0001836368,0.0001881132,0.000009442672,0.00003995419,0.000002153675,0.001131903],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002363975,"threshold_uncertainty_score":0.007908285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1212620894779605,"score_gpt":0.3606021485271227,"score_spread":0.2393400590491622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}