{"id":"W2783286959","doi":"10.1371/journal.pone.0191178","title":"Flow cytometric analysis identifies changes in S and M phases as novel cell cycle alterations induced by the splicing inhibitor isoginkgetin","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ottawa Hospital Research Institute; Carleton University; Johns Hopkins University","keywords":"Spliceosome; RNA splicing; Cell cycle; Cell biology; Intron; Biology; Ribonucleoprotein; Flow cytometry; RNA; Molecular biology; Chemistry; Cell; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001527152,0.0001942293,0.0002674186,0.0005030833,0.0001367493,0.0002006455,0.0002286786,0.0003086819,0.001430184],"category_scores_gemma":[0.0001088767,0.00008896938,0.0001695853,0.0003328987,0.000126924,0.0001582958,0.00009300366,0.0004873565,0.0002140389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002515895,"about_ca_system_score_gemma":0.000138407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006508379,"about_ca_topic_score_gemma":0.0005938029,"domain_scores_codex":[0.9998689,0.00002455181,0.00001412748,0.00002708608,0.00003464617,0.00003058473],"domain_scores_gemma":[0.9998697,0.00003568376,0.00002426959,0.0000112514,0.00003273046,0.00002628371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002597521,0.00007565541,0.0004343927,0.00002220431,0.000004654099,0.00003067344,0.00002254811,0.00004981341,0.9966233,0.00007828204,0.00005008603,0.00234872],"study_design_scores_gemma":[0.00003440691,0.0006043048,0.01909961,0.000007154495,0.00001758778,0.0001215466,0.00005234198,0.002430487,0.97624,0.00009647596,0.001288021,0.000008004887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872786,0.002502705,0.00583782,0.0001660306,0.00005255942,0.000101646,0.0006879213,0.0001799639,0.00319281],"genre_scores_gemma":[0.9882609,0.001638325,0.005812404,0.0001801791,0.00004067907,0.0002410246,0.0006821021,0.00002382103,0.00312052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001430184,"threshold_uncertainty_score":0.004784465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03147537566781542,"score_gpt":0.2781942176456249,"score_spread":0.2467188419778094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}